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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EZH1
All Species:
23.94
Human Site:
S226
Identified Species:
40.51
UniProt:
Q92800
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92800
NP_001982.2
747
85271
S226
A
I
E
G
N
K
K
S
S
K
K
Q
F
P
N
Chimpanzee
Pan troglodytes
XP_001160955
703
80167
H218
V
T
R
K
R
K
R
H
A
I
E
G
N
K
K
Rhesus Macaque
Macaca mulatta
XP_001111476
747
85257
S226
A
I
E
G
N
K
K
S
S
K
K
Q
F
P
N
Dog
Lupus familis
XP_849127
759
86729
S226
A
L
E
G
N
K
K
S
S
K
K
Q
F
P
N
Cat
Felis silvestris
Mouse
Mus musculus
P70351
747
85169
S226
A
I
E
G
N
K
K
S
S
K
K
Q
F
P
N
Rat
Rattus norvegicus
NP_001100521
747
85331
S226
A
I
E
G
N
K
K
S
S
K
K
Q
F
P
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505650
747
85501
F225
K
F
P
S
D
K
I
F
E
A
I
S
S
M
F
Chicken
Gallus gallus
XP_418144
746
85486
S226
V
E
G
N
K
K
C
S
K
K
R
F
P
N
D
Frog
Xenopus laevis
Q98SM3
748
85365
I225
R
K
F
P
S
D
K
I
F
E
A
I
S
S
M
Zebra Danio
Brachydanio rerio
Q08BS4
760
87127
D226
S
S
E
S
H
N
N
D
G
S
K
K
F
P
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P42124
760
86917
E230
D
S
K
G
D
L
T
E
V
E
K
K
E
T
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O17514
773
88803
S247
A
L
K
D
Y
Q
G
S
P
D
V
F
Y
Y
T
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q8S4P6
931
103750
V343
W
S
G
V
D
D
S
V
P
C
G
I
H
C
H
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9ZSM8
856
95378
Y225
A
S
D
I
L
E
R
Y
N
E
L
K
L
K
D
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.1
99.7
95.5
N.A.
97.8
97.8
N.A.
64.1
91.6
63.7
63
N.A.
51.4
N.A.
21.8
N.A.
Protein Similarity:
100
94.1
100
97
N.A.
98.9
98.8
N.A.
77.6
95.3
76.8
76.3
N.A.
65.6
N.A.
40.4
N.A.
P-Site Identity:
100
6.6
100
93.3
N.A.
100
100
N.A.
6.6
20
6.6
26.6
N.A.
13.3
N.A.
13.3
N.A.
P-Site Similarity:
100
26.6
100
100
N.A.
100
100
N.A.
13.3
33.3
20
53.3
N.A.
40
N.A.
40
N.A.
Percent
Protein Identity:
N.A.
27.5
N.A.
25.3
N.A.
N.A.
Protein Similarity:
N.A.
42.6
N.A.
42.7
N.A.
N.A.
P-Site Identity:
N.A.
0
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
13.3
N.A.
53.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
50
0
0
0
0
0
0
0
8
8
8
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
8
0
0
8
0
0
0
8
0
% C
% Asp:
8
0
8
8
22
15
0
8
0
8
0
0
0
0
15
% D
% Glu:
0
8
43
0
0
8
0
8
8
22
8
0
8
0
8
% E
% Phe:
0
8
8
0
0
0
0
8
8
0
0
15
43
0
8
% F
% Gly:
0
0
15
43
0
0
8
0
8
0
8
8
0
0
0
% G
% His:
0
0
0
0
8
0
0
8
0
0
0
0
8
0
8
% H
% Ile:
0
29
0
8
0
0
8
8
0
8
8
15
0
0
0
% I
% Lys:
8
8
15
8
8
58
43
0
8
43
50
22
0
15
8
% K
% Leu:
0
15
0
0
8
8
0
0
0
0
8
0
8
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
8
% M
% Asn:
0
0
0
8
36
8
8
0
8
0
0
0
8
8
36
% N
% Pro:
0
0
8
8
0
0
0
0
15
0
0
0
8
43
0
% P
% Gln:
0
0
0
0
0
8
0
0
0
0
0
36
0
0
0
% Q
% Arg:
8
0
8
0
8
0
15
0
0
0
8
0
0
0
0
% R
% Ser:
8
29
0
15
8
0
8
50
36
8
0
8
15
8
8
% S
% Thr:
0
8
0
0
0
0
8
0
0
0
0
0
0
8
8
% T
% Val:
15
0
0
8
0
0
0
8
8
0
8
0
0
0
0
% V
% Trp:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
0
8
0
0
0
0
8
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _