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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EZH1
All Species:
23.64
Human Site:
S290
Identified Species:
40
UniProt:
Q92800
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92800
NP_001982.2
747
85271
S290
K
S
V
Q
R
E
Q
S
L
H
S
F
H
T
L
Chimpanzee
Pan troglodytes
XP_001160955
703
80167
A282
P
N
I
D
G
P
N
A
K
S
V
Q
R
E
Q
Rhesus Macaque
Macaca mulatta
XP_001111476
747
85257
S290
K
S
V
Q
R
E
Q
S
L
H
S
F
H
T
L
Dog
Lupus familis
XP_849127
759
86729
S290
K
S
V
Q
R
E
Q
S
L
H
S
F
H
T
L
Cat
Felis silvestris
Mouse
Mus musculus
P70351
747
85169
S290
K
S
V
Q
R
E
Q
S
L
H
S
F
H
T
L
Rat
Rattus norvegicus
NP_001100521
747
85331
S290
K
S
V
Q
R
E
Q
S
L
H
S
F
H
T
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505650
747
85501
R289
F
H
T
L
F
C
R
R
C
F
K
Y
D
C
F
Chicken
Gallus gallus
XP_418144
746
85486
L290
S
V
Q
R
E
Q
S
L
H
S
F
H
T
L
F
Frog
Xenopus laevis
Q98SM3
748
85365
R289
S
F
H
T
L
F
C
R
P
C
F
K
Y
D
C
Zebra Danio
Brachydanio rerio
Q08BS4
760
87127
S290
K
S
V
Q
R
E
Q
S
L
H
S
F
H
T
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P42124
760
86917
D294
I
E
L
T
E
H
Q
D
P
E
R
P
Q
E
C
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O17514
773
88803
A311
L
R
N
P
T
C
Y
A
C
L
A
Y
T
C
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q8S4P6
931
103750
T407
Q
Q
S
E
S
S
S
T
A
R
V
I
S
E
S
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9ZSM8
856
95378
K289
P
L
I
S
A
S
E
K
Q
P
Y
W
S
D
Y
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.1
99.7
95.5
N.A.
97.8
97.8
N.A.
64.1
91.6
63.7
63
N.A.
51.4
N.A.
21.8
N.A.
Protein Similarity:
100
94.1
100
97
N.A.
98.9
98.8
N.A.
77.6
95.3
76.8
76.3
N.A.
65.6
N.A.
40.4
N.A.
P-Site Identity:
100
0
100
100
N.A.
100
100
N.A.
0
0
0
100
N.A.
6.6
N.A.
0
N.A.
P-Site Similarity:
100
20
100
100
N.A.
100
100
N.A.
13.3
13.3
6.6
100
N.A.
13.3
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
27.5
N.A.
25.3
N.A.
N.A.
Protein Similarity:
N.A.
42.6
N.A.
42.7
N.A.
N.A.
P-Site Identity:
N.A.
0
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
20
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
0
0
15
8
0
8
0
0
0
8
% A
% Cys:
0
0
0
0
0
15
8
0
15
8
0
0
0
15
15
% C
% Asp:
0
0
0
8
0
0
0
8
0
0
0
0
8
15
0
% D
% Glu:
0
8
0
8
15
43
8
0
0
8
0
0
0
22
0
% E
% Phe:
8
8
0
0
8
8
0
0
0
8
15
43
0
0
15
% F
% Gly:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
8
8
0
0
8
0
0
8
43
0
8
43
0
0
% H
% Ile:
8
0
15
0
0
0
0
0
0
0
0
8
0
0
0
% I
% Lys:
43
0
0
0
0
0
0
8
8
0
8
8
0
0
0
% K
% Leu:
8
8
8
8
8
0
0
8
43
8
0
0
0
8
43
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
8
0
0
0
8
0
0
0
0
0
0
0
0
% N
% Pro:
15
0
0
8
0
8
0
0
15
8
0
8
0
0
0
% P
% Gln:
8
8
8
43
0
8
50
0
8
0
0
8
8
0
8
% Q
% Arg:
0
8
0
8
43
0
8
15
0
8
8
0
8
0
0
% R
% Ser:
15
43
8
8
8
15
15
43
0
15
43
0
15
0
8
% S
% Thr:
0
0
8
15
8
0
0
8
0
0
0
0
15
43
0
% T
% Val:
0
8
43
0
0
0
0
0
0
0
15
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% W
% Tyr:
0
0
0
0
0
0
8
0
0
0
8
15
8
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _