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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EZH1
All Species:
18.18
Human Site:
S490
Identified Species:
30.77
UniProt:
Q92800
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92800
NP_001982.2
747
85271
S490
T
D
E
L
M
N
P
S
Q
K
K
K
R
K
H
Chimpanzee
Pan troglodytes
XP_001160955
703
80167
L481
K
E
S
L
I
L
K
L
P
T
D
E
L
M
N
Rhesus Macaque
Macaca mulatta
XP_001111476
747
85257
S490
T
D
E
L
M
N
P
S
Q
K
K
K
R
K
H
Dog
Lupus familis
XP_849127
759
86729
S502
T
D
E
L
M
N
P
S
Q
K
K
K
R
K
H
Cat
Felis silvestris
Mouse
Mus musculus
P70351
747
85169
A490
T
D
E
L
M
N
P
A
Q
K
K
K
R
K
H
Rat
Rattus norvegicus
NP_001100521
747
85331
S490
T
D
E
L
M
N
P
S
Q
K
K
K
R
K
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505650
747
85501
P489
P
A
E
D
V
D
T
P
P
R
K
K
K
R
K
Chicken
Gallus gallus
XP_418144
746
85486
S489
T
N
E
L
M
N
P
S
Q
K
K
K
R
K
H
Frog
Xenopus laevis
Q98SM3
748
85365
P490
I
A
E
D
V
D
T
P
P
R
K
K
K
R
K
Zebra Danio
Brachydanio rerio
Q08BS4
760
87127
P502
P
A
V
D
E
N
T
P
Q
R
K
K
K
R
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P42124
760
86917
P503
D
L
R
Q
D
F
T
P
P
R
K
K
K
K
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O17514
773
88803
D512
I
R
E
D
D
M
R
D
S
Q
R
N
S
E
K
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q8S4P6
931
103750
G630
G
V
D
S
L
V
K
G
Y
I
K
G
T
E
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9ZSM8
856
95378
E537
S
N
Y
M
R
E
N
E
V
S
V
F
R
R
S
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.1
99.7
95.5
N.A.
97.8
97.8
N.A.
64.1
91.6
63.7
63
N.A.
51.4
N.A.
21.8
N.A.
Protein Similarity:
100
94.1
100
97
N.A.
98.9
98.8
N.A.
77.6
95.3
76.8
76.3
N.A.
65.6
N.A.
40.4
N.A.
P-Site Identity:
100
6.6
100
100
N.A.
93.3
100
N.A.
20
93.3
20
26.6
N.A.
20
N.A.
6.6
N.A.
P-Site Similarity:
100
33.3
100
100
N.A.
100
100
N.A.
53.3
100
53.3
46.6
N.A.
33.3
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
27.5
N.A.
25.3
N.A.
N.A.
Protein Similarity:
N.A.
42.6
N.A.
42.7
N.A.
N.A.
P-Site Identity:
N.A.
6.6
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
26.6
N.A.
33.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
22
0
0
0
0
0
8
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
36
8
29
15
15
0
8
0
0
8
0
0
0
0
% D
% Glu:
0
8
65
0
8
8
0
8
0
0
0
8
0
15
0
% E
% Phe:
0
0
0
0
0
8
0
0
0
0
0
8
0
0
0
% F
% Gly:
8
0
0
0
0
0
0
8
0
0
0
8
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
43
% H
% Ile:
15
0
0
0
8
0
0
0
0
8
0
0
0
0
0
% I
% Lys:
8
0
0
0
0
0
15
0
0
43
79
72
29
50
36
% K
% Leu:
0
8
0
50
8
8
0
8
0
0
0
0
8
0
8
% L
% Met:
0
0
0
8
43
8
0
0
0
0
0
0
0
8
0
% M
% Asn:
0
15
0
0
0
50
8
0
0
0
0
8
0
0
8
% N
% Pro:
15
0
0
0
0
0
43
29
29
0
0
0
0
0
0
% P
% Gln:
0
0
0
8
0
0
0
0
50
8
0
0
0
0
0
% Q
% Arg:
0
8
8
0
8
0
8
0
0
29
8
0
50
29
0
% R
% Ser:
8
0
8
8
0
0
0
36
8
8
0
0
8
0
8
% S
% Thr:
43
0
0
0
0
0
29
0
0
8
0
0
8
0
0
% T
% Val:
0
8
8
0
15
8
0
0
8
0
8
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
0
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _