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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EZH1
All Species:
52.73
Human Site:
S648
Identified Species:
89.23
UniProt:
Q92800
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92800
NP_001982.2
747
85271
S648
E
Y
C
G
E
L
I
S
Q
D
E
A
D
R
R
Chimpanzee
Pan troglodytes
XP_001160955
703
80167
S620
K
H
L
L
L
A
P
S
D
V
A
G
W
G
T
Rhesus Macaque
Macaca mulatta
XP_001111476
747
85257
S648
E
Y
C
G
E
L
I
S
Q
D
E
A
D
R
R
Dog
Lupus familis
XP_849127
759
86729
S660
E
Y
C
G
E
L
I
S
Q
D
E
A
D
R
R
Cat
Felis silvestris
Mouse
Mus musculus
P70351
747
85169
S648
E
Y
C
G
E
L
I
S
Q
D
E
A
D
R
R
Rat
Rattus norvegicus
NP_001100521
747
85331
S648
E
Y
C
G
E
L
I
S
Q
D
E
A
D
R
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505650
747
85501
S648
E
Y
C
G
E
I
I
S
Q
D
E
A
D
R
R
Chicken
Gallus gallus
XP_418144
746
85486
S647
E
Y
C
G
E
L
I
S
Q
D
E
A
D
R
R
Frog
Xenopus laevis
Q98SM3
748
85365
S649
E
Y
C
G
E
I
I
S
Q
D
E
A
D
R
R
Zebra Danio
Brachydanio rerio
Q08BS4
760
87127
S661
E
Y
C
G
E
I
I
S
Q
D
E
A
D
R
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P42124
760
86917
S661
E
Y
C
G
E
I
I
S
Q
D
E
A
D
R
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O17514
773
88803
S656
E
Y
T
G
E
R
I
S
D
D
E
A
E
R
R
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q8S4P6
931
103750
S813
E
Y
T
G
E
L
I
S
H
K
E
A
D
K
R
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9ZSM8
856
95378
S742
E
Y
T
G
E
L
I
S
H
H
E
A
D
K
R
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.1
99.7
95.5
N.A.
97.8
97.8
N.A.
64.1
91.6
63.7
63
N.A.
51.4
N.A.
21.8
N.A.
Protein Similarity:
100
94.1
100
97
N.A.
98.9
98.8
N.A.
77.6
95.3
76.8
76.3
N.A.
65.6
N.A.
40.4
N.A.
P-Site Identity:
100
6.6
100
100
N.A.
100
100
N.A.
93.3
100
93.3
93.3
N.A.
93.3
N.A.
73.3
N.A.
P-Site Similarity:
100
20
100
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
100
N.A.
80
N.A.
Percent
Protein Identity:
N.A.
27.5
N.A.
25.3
N.A.
N.A.
Protein Similarity:
N.A.
42.6
N.A.
42.7
N.A.
N.A.
P-Site Identity:
N.A.
73.3
N.A.
73.3
N.A.
N.A.
P-Site Similarity:
N.A.
80
N.A.
80
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
8
0
0
0
0
8
93
0
0
0
% A
% Cys:
0
0
72
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
15
79
0
0
86
0
0
% D
% Glu:
93
0
0
0
93
0
0
0
0
0
93
0
8
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
93
0
0
0
0
0
0
0
8
0
8
0
% G
% His:
0
8
0
0
0
0
0
0
15
8
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
29
93
0
0
0
0
0
0
0
0
% I
% Lys:
8
0
0
0
0
0
0
0
0
8
0
0
0
15
0
% K
% Leu:
0
0
8
8
8
58
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
72
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
8
0
0
0
0
0
0
0
79
93
% R
% Ser:
0
0
0
0
0
0
0
100
0
0
0
0
0
0
0
% S
% Thr:
0
0
22
0
0
0
0
0
0
0
0
0
0
0
8
% T
% Val:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% W
% Tyr:
0
93
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _