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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EZH1
All Species:
38.79
Human Site:
S730
Identified Species:
65.64
UniProt:
Q92800
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92800
NP_001982.2
747
85271
S730
L
F
F
D
Y
R
Y
S
Q
A
D
A
L
K
Y
Chimpanzee
Pan troglodytes
XP_001160955
703
80167
F687
R
K
G
N
K
I
R
F
A
N
H
S
V
N
P
Rhesus Macaque
Macaca mulatta
XP_001111476
747
85257
S730
L
F
F
D
Y
R
Y
S
Q
A
D
A
L
K
Y
Dog
Lupus familis
XP_849127
759
86729
S742
L
F
F
D
Y
R
Y
S
Q
A
D
A
L
K
Y
Cat
Felis silvestris
Mouse
Mus musculus
P70351
747
85169
S730
L
F
F
D
Y
R
Y
S
Q
A
D
A
L
K
Y
Rat
Rattus norvegicus
NP_001100521
747
85331
S730
L
F
F
D
Y
R
Y
S
Q
A
D
A
L
K
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505650
747
85501
S730
L
F
F
D
Y
R
Y
S
Q
A
D
A
L
K
Y
Chicken
Gallus gallus
XP_418144
746
85486
S729
L
F
F
D
Y
R
Y
S
Q
A
D
A
L
K
Y
Frog
Xenopus laevis
Q98SM3
748
85365
S731
L
F
F
D
Y
R
Y
S
Q
A
D
A
L
K
Y
Zebra Danio
Brachydanio rerio
Q08BS4
760
87127
S743
L
F
F
D
Y
R
Y
S
Q
A
D
A
L
K
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P42124
760
86917
G743
L
F
F
D
Y
R
Y
G
P
T
E
Q
L
K
F
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O17514
773
88803
S739
L
T
F
D
Y
S
Y
S
G
E
H
Q
I
A
F
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q8S4P6
931
103750
E895
L
F
Y
D
Y
R
Y
E
P
D
R
A
P
A
W
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9ZSM8
856
95378
G824
L
F
Y
D
Y
R
Y
G
P
D
Q
A
P
V
W
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.1
99.7
95.5
N.A.
97.8
97.8
N.A.
64.1
91.6
63.7
63
N.A.
51.4
N.A.
21.8
N.A.
Protein Similarity:
100
94.1
100
97
N.A.
98.9
98.8
N.A.
77.6
95.3
76.8
76.3
N.A.
65.6
N.A.
40.4
N.A.
P-Site Identity:
100
0
100
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
60
N.A.
40
N.A.
P-Site Similarity:
100
20
100
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
73.3
N.A.
53.3
N.A.
Percent
Protein Identity:
N.A.
27.5
N.A.
25.3
N.A.
N.A.
Protein Similarity:
N.A.
42.6
N.A.
42.7
N.A.
N.A.
P-Site Identity:
N.A.
46.6
N.A.
46.6
N.A.
N.A.
P-Site Similarity:
N.A.
60
N.A.
60
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
8
65
0
79
0
15
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
93
0
0
0
0
0
15
65
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
8
0
8
8
0
0
0
0
% E
% Phe:
0
86
79
0
0
0
0
8
0
0
0
0
0
0
15
% F
% Gly:
0
0
8
0
0
0
0
15
8
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
15
0
0
0
0
% H
% Ile:
0
0
0
0
0
8
0
0
0
0
0
0
8
0
0
% I
% Lys:
0
8
0
0
8
0
0
0
0
0
0
0
0
72
0
% K
% Leu:
93
0
0
0
0
0
0
0
0
0
0
0
72
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
8
0
0
0
0
0
8
0
0
0
8
0
% N
% Pro:
0
0
0
0
0
0
0
0
22
0
0
0
15
0
8
% P
% Gln:
0
0
0
0
0
0
0
0
65
0
8
15
0
0
0
% Q
% Arg:
8
0
0
0
0
86
8
0
0
0
8
0
0
0
0
% R
% Ser:
0
0
0
0
0
8
0
72
0
0
0
8
0
0
0
% S
% Thr:
0
8
0
0
0
0
0
0
0
8
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
8
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
15
% W
% Tyr:
0
0
15
0
93
0
93
0
0
0
0
0
0
0
65
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _