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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EZH1
All Species:
37.88
Human Site:
Y23
Identified Species:
64.1
UniProt:
Q92800
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92800
NP_001982.2
747
85271
Y23
K
R
K
V
K
S
E
Y
M
R
L
R
Q
L
K
Chimpanzee
Pan troglodytes
XP_001160955
703
80167
S21
Y
W
K
R
K
V
K
S
E
Y
M
R
L
R
Q
Rhesus Macaque
Macaca mulatta
XP_001111476
747
85257
Y23
K
R
K
V
K
S
E
Y
M
R
L
R
Q
L
K
Dog
Lupus familis
XP_849127
759
86729
Y23
K
R
K
V
K
S
E
Y
M
R
L
R
Q
L
K
Cat
Felis silvestris
Mouse
Mus musculus
P70351
747
85169
Y23
K
R
K
V
K
S
E
Y
M
R
L
R
Q
L
K
Rat
Rattus norvegicus
NP_001100521
747
85331
Y23
K
R
K
V
K
S
E
Y
M
R
L
R
Q
L
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505650
747
85501
Y23
R
K
R
V
K
S
E
Y
M
R
L
R
Q
L
K
Chicken
Gallus gallus
XP_418144
746
85486
Y23
K
R
K
V
K
S
E
Y
M
R
L
R
Q
L
K
Frog
Xenopus laevis
Q98SM3
748
85365
Y23
R
K
R
V
K
S
E
Y
M
A
L
R
Q
L
K
Zebra Danio
Brachydanio rerio
Q08BS4
760
87127
Y23
R
R
R
V
K
S
E
Y
M
R
L
R
Q
L
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P42124
760
86917
R26
I
K
I
R
Q
Q
K
R
Y
K
R
A
D
E
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O17514
773
88803
E23
K
K
R
G
K
K
C
E
T
S
M
G
K
S
K
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q8S4P6
931
103750
R65
K
K
R
I
T
A
D
R
L
T
Y
I
K
N
R
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9ZSM8
856
95378
E26
D
D
D
G
E
E
E
E
D
R
L
E
G
L
E
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.1
99.7
95.5
N.A.
97.8
97.8
N.A.
64.1
91.6
63.7
63
N.A.
51.4
N.A.
21.8
N.A.
Protein Similarity:
100
94.1
100
97
N.A.
98.9
98.8
N.A.
77.6
95.3
76.8
76.3
N.A.
65.6
N.A.
40.4
N.A.
P-Site Identity:
100
20
100
100
N.A.
100
100
N.A.
80
100
73.3
86.6
N.A.
0
N.A.
20
N.A.
P-Site Similarity:
100
40
100
100
N.A.
100
100
N.A.
100
100
93.3
100
N.A.
26.6
N.A.
46.6
N.A.
Percent
Protein Identity:
N.A.
27.5
N.A.
25.3
N.A.
N.A.
Protein Similarity:
N.A.
42.6
N.A.
42.7
N.A.
N.A.
P-Site Identity:
N.A.
6.6
N.A.
26.6
N.A.
N.A.
P-Site Similarity:
N.A.
60
N.A.
40
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
8
0
0
0
8
0
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% C
% Asp:
8
8
8
0
0
0
8
0
8
0
0
0
8
0
0
% D
% Glu:
0
0
0
0
8
8
72
15
8
0
0
8
0
8
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
15
0
0
0
0
0
0
0
8
8
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
8
8
0
0
0
0
0
0
0
8
0
0
8
% I
% Lys:
58
36
50
0
79
8
15
0
0
8
0
0
15
0
72
% K
% Leu:
0
0
0
0
0
0
0
0
8
0
72
0
8
72
0
% L
% Met:
0
0
0
0
0
0
0
0
65
0
15
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
8
8
0
0
0
0
0
0
65
0
8
% Q
% Arg:
22
50
36
15
0
0
0
15
0
65
8
72
0
8
8
% R
% Ser:
0
0
0
0
0
65
0
8
0
8
0
0
0
8
0
% S
% Thr:
0
0
0
0
8
0
0
0
8
8
0
0
0
0
0
% T
% Val:
0
0
0
65
0
8
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
65
8
8
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _