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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PCSK5
All Species:
33.64
Human Site:
S336
Identified Species:
61.67
UniProt:
Q92824
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92824
NP_006191.2
913
101649
S336
S
I
Y
T
I
S
I
S
S
T
A
E
S
G
K
Chimpanzee
Pan troglodytes
XP_520079
1860
206955
S336
S
I
Y
T
I
S
I
S
S
T
A
E
S
G
K
Rhesus Macaque
Macaca mulatta
XP_001094068
794
86687
H246
S
L
G
L
N
P
N
H
I
H
I
Y
S
A
S
Dog
Lupus familis
XP_541276
1883
209497
S334
S
I
Y
T
I
S
I
S
S
T
A
E
S
G
K
Cat
Felis silvestris
Mouse
Mus musculus
Q04592
1877
209270
S338
S
I
Y
T
I
S
I
S
S
T
A
E
S
G
K
Rat
Rattus norvegicus
P41413
1877
199778
S338
S
I
Y
T
I
S
I
S
S
T
A
E
S
G
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507677
642
72067
M94
S
S
R
C
R
T
E
M
N
V
P
A
A
W
K
Chicken
Gallus gallus
XP_424841
1853
207276
S328
S
I
Y
T
I
S
I
S
S
T
A
E
S
G
K
Frog
Xenopus laevis
P29119
783
86425
A235
E
V
T
D
A
V
E
A
R
S
L
G
L
N
P
Zebra Danio
Brachydanio rerio
NP_001077298
917
101996
S341
S
I
Y
T
I
S
I
S
S
T
A
E
S
G
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30432
1679
183351
S580
S
I
F
T
L
S
I
S
S
A
T
Q
A
G
F
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P51559
943
103128
S365
S
V
Y
T
L
S
I
S
S
A
T
Y
D
N
H
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13134
814
89984
V265
S
L
I
Y
G
L
D
V
N
D
I
Y
S
C
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
48.8
42.8
44
N.A.
45.8
45.4
N.A.
46.9
39.4
42.2
70.6
N.A.
29
N.A.
35.7
N.A.
Protein Similarity:
100
49
54.4
45.1
N.A.
47.4
46.7
N.A.
57
43.5
55.5
81.9
N.A.
37.1
N.A.
48
N.A.
P-Site Identity:
100
100
13.3
100
N.A.
100
100
N.A.
13.3
100
0
93.3
N.A.
53.3
N.A.
46.6
N.A.
P-Site Similarity:
100
100
20
100
N.A.
100
100
N.A.
33.3
100
20
100
N.A.
80
N.A.
60
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
28.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
0
0
8
0
16
54
8
16
8
0
% A
% Cys:
0
0
0
8
0
0
0
0
0
0
0
0
0
8
0
% C
% Asp:
0
0
0
8
0
0
8
0
0
8
0
0
8
0
0
% D
% Glu:
8
0
0
0
0
0
16
0
0
0
0
54
0
0
0
% E
% Phe:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
8
% F
% Gly:
0
0
8
0
8
0
0
0
0
0
0
8
0
62
0
% G
% His:
0
0
0
0
0
0
0
8
0
8
0
0
0
0
8
% H
% Ile:
0
62
8
0
54
0
70
0
8
0
16
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
54
% K
% Leu:
0
16
0
8
16
8
0
0
0
0
8
0
8
0
0
% L
% Met:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
8
0
8
0
16
0
0
0
0
16
0
% N
% Pro:
0
0
0
0
0
8
0
0
0
0
8
0
0
0
8
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% Q
% Arg:
0
0
8
0
8
0
0
0
8
0
0
0
0
0
8
% R
% Ser:
93
8
0
0
0
70
0
70
70
8
0
0
70
0
16
% S
% Thr:
0
0
8
70
0
8
0
0
0
54
16
0
0
0
0
% T
% Val:
0
16
0
0
0
8
0
8
0
8
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% W
% Tyr:
0
0
62
8
0
0
0
0
0
0
0
24
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _