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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PCSK5
All Species:
13.64
Human Site:
T722
Identified Species:
25
UniProt:
Q92824
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92824
NP_006191.2
913
101649
T722
E
E
T
N
S
C
V
T
H
C
P
D
G
S
Y
Chimpanzee
Pan troglodytes
XP_520079
1860
206955
T722
E
E
T
N
S
C
V
T
H
C
P
D
G
S
Y
Rhesus Macaque
Macaca mulatta
XP_001094068
794
86687
A619
Q
H
C
P
P
G
F
A
P
Q
V
L
D
T
H
Dog
Lupus familis
XP_541276
1883
209497
I720
E
E
I
N
S
C
V
I
H
C
P
D
G
S
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q04592
1877
209270
T724
E
E
T
S
S
C
V
T
Q
C
P
D
G
S
Y
Rat
Rattus norvegicus
P41413
1877
199778
A724
E
E
T
S
S
C
V
A
Q
C
P
E
G
S
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507677
642
72067
Q467
H
P
R
R
G
D
L
Q
I
H
L
I
S
P
S
Chicken
Gallus gallus
XP_424841
1853
207276
T714
E
V
T
N
S
C
I
T
T
C
P
D
G
F
Y
Frog
Xenopus laevis
P29119
783
86425
C608
Y
F
L
H
Q
K
S
C
I
K
S
C
P
Q
G
Zebra Danio
Brachydanio rerio
NP_001077298
917
101996
G726
C
I
S
S
C
P
D
G
F
Y
L
D
L
E
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30432
1679
183351
V1244
L
L
E
Q
S
R
C
V
S
G
C
R
E
G
F
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P51559
943
103128
H761
I
D
V
D
N
M
P
H
Y
D
H
G
K
C
V
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13134
814
89984
S639
S
I
S
A
T
S
T
S
S
I
S
I
G
V
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
48.8
42.8
44
N.A.
45.8
45.4
N.A.
46.9
39.4
42.2
70.6
N.A.
29
N.A.
35.7
N.A.
Protein Similarity:
100
49
54.4
45.1
N.A.
47.4
46.7
N.A.
57
43.5
55.5
81.9
N.A.
37.1
N.A.
48
N.A.
P-Site Identity:
100
100
0
86.6
N.A.
86.6
73.3
N.A.
0
73.3
0
6.6
N.A.
6.6
N.A.
0
N.A.
P-Site Similarity:
100
100
20
86.6
N.A.
93.3
86.6
N.A.
6.6
80
6.6
20
N.A.
13.3
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
28.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
0
0
16
0
0
0
0
0
0
0
% A
% Cys:
8
0
8
0
8
47
8
8
0
47
8
8
0
8
0
% C
% Asp:
0
8
0
8
0
8
8
0
0
8
0
47
8
0
0
% D
% Glu:
47
39
8
0
0
0
0
0
0
0
0
8
8
8
8
% E
% Phe:
0
8
0
0
0
0
8
0
8
0
0
0
0
8
8
% F
% Gly:
0
0
0
0
8
8
0
8
0
8
0
8
54
8
8
% G
% His:
8
8
0
8
0
0
0
8
24
8
8
0
0
0
8
% H
% Ile:
8
16
8
0
0
0
8
8
16
8
0
16
0
0
0
% I
% Lys:
0
0
0
0
0
8
0
0
0
8
0
0
8
0
0
% K
% Leu:
8
8
8
0
0
0
8
0
0
0
16
8
8
0
0
% L
% Met:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
31
8
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
8
0
8
8
8
8
0
8
0
47
0
8
8
0
% P
% Gln:
8
0
0
8
8
0
0
8
16
8
0
0
0
8
0
% Q
% Arg:
0
0
8
8
0
8
0
0
0
0
0
8
0
0
0
% R
% Ser:
8
0
16
24
54
8
8
8
16
0
16
0
8
39
16
% S
% Thr:
0
0
39
0
8
0
8
31
8
0
0
0
0
8
0
% T
% Val:
0
8
8
0
0
0
39
8
0
0
8
0
0
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
0
8
8
0
0
0
0
47
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _