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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PCSK5
All Species:
26.06
Human Site:
Y489
Identified Species:
47.78
UniProt:
Q92824
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92824
NP_006191.2
913
101649
Y489
N
S
A
V
R
S
I
Y
K
A
S
G
C
S
D
Chimpanzee
Pan troglodytes
XP_520079
1860
206955
Y489
N
S
A
V
R
S
I
Y
K
A
S
G
C
S
D
Rhesus Macaque
Macaca mulatta
XP_001094068
794
86687
D392
N
K
N
L
T
W
R
D
M
Q
H
L
V
V
Q
Dog
Lupus familis
XP_541276
1883
209497
Y487
N
S
A
V
R
S
I
Y
K
A
S
G
C
S
D
Cat
Felis silvestris
Mouse
Mus musculus
Q04592
1877
209270
Y491
N
S
A
V
R
S
I
Y
K
A
S
G
C
S
D
Rat
Rattus norvegicus
P41413
1877
199778
Y491
N
S
A
V
R
S
I
Y
K
A
S
G
C
S
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507677
642
72067
I240
K
Q
A
F
E
Y
G
I
Q
K
G
R
G
G
L
Chicken
Gallus gallus
XP_424841
1853
207276
Y481
D
S
V
V
R
S
I
Y
K
A
T
G
C
S
D
Frog
Xenopus laevis
P29119
783
86425
E381
G
I
I
A
L
A
L
E
A
N
K
N
L
T
W
Zebra Danio
Brachydanio rerio
NP_001077298
917
101996
Y494
E
H
V
V
R
S
V
Y
K
A
T
G
C
T
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30432
1679
183351
H742
Y
G
S
T
L
S
T
H
M
D
V
N
G
C
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P51559
943
103128
F520
V
G
R
F
Q
L
N
F
T
L
D
V
N
G
C
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13134
814
89984
Q411
N
L
T
W
R
D
V
Q
Y
L
S
I
L
S
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
48.8
42.8
44
N.A.
45.8
45.4
N.A.
46.9
39.4
42.2
70.6
N.A.
29
N.A.
35.7
N.A.
Protein Similarity:
100
49
54.4
45.1
N.A.
47.4
46.7
N.A.
57
43.5
55.5
81.9
N.A.
37.1
N.A.
48
N.A.
P-Site Identity:
100
100
6.6
100
N.A.
100
100
N.A.
6.6
80
0
60
N.A.
6.6
N.A.
0
N.A.
P-Site Similarity:
100
100
13.3
100
N.A.
100
100
N.A.
13.3
93.3
20
80
N.A.
20
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
28.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
47
8
0
8
0
0
8
54
0
0
0
0
16
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
54
8
8
% C
% Asp:
8
0
0
0
0
8
0
8
0
8
8
0
0
0
54
% D
% Glu:
8
0
0
0
8
0
0
8
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
16
0
0
0
8
0
0
0
0
0
0
0
% F
% Gly:
8
16
0
0
0
0
8
0
0
0
8
54
16
16
0
% G
% His:
0
8
0
0
0
0
0
8
0
0
8
0
0
0
0
% H
% Ile:
0
8
8
0
0
0
47
8
0
0
0
8
0
0
0
% I
% Lys:
8
8
0
0
0
0
0
0
54
8
8
0
0
0
0
% K
% Leu:
0
8
0
8
16
8
8
0
0
16
0
8
16
0
8
% L
% Met:
0
0
0
0
0
0
0
0
16
0
0
0
0
0
0
% M
% Asn:
54
0
8
0
0
0
8
0
0
8
0
16
8
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
8
0
0
8
0
0
8
8
8
0
0
0
0
8
% Q
% Arg:
0
0
8
0
62
0
8
0
0
0
0
8
0
0
0
% R
% Ser:
0
47
8
0
0
62
0
0
0
0
47
0
0
54
0
% S
% Thr:
0
0
8
8
8
0
8
0
8
0
16
0
0
16
0
% T
% Val:
8
0
16
54
0
0
16
0
0
0
8
8
8
8
0
% V
% Trp:
0
0
0
8
0
8
0
0
0
0
0
0
0
0
8
% W
% Tyr:
8
0
0
0
0
8
0
54
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _