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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PCSK5 All Species: 29.09
Human Site: Y504 Identified Species: 53.33
UniProt: Q92824 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q92824 NP_006191.2 913 101649 Y504 N P N R H V N Y L E H V V V R
Chimpanzee Pan troglodytes XP_520079 1860 206955 Y504 N P N R H V N Y L E H V V V R
Rhesus Macaque Macaca mulatta XP_001094068 794 86687 N407 T S K P A H L N A N D W A T N
Dog Lupus familis XP_541276 1883 209497 Y502 N P N H H V N Y L E H V V V R
Cat Felis silvestris
Mouse Mus musculus Q04592 1877 209270 Y506 N P N H H V N Y L E H V V V R
Rat Rattus norvegicus P41413 1877 199778 Y506 N P N H H V N Y L E H V V V R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507677 642 72067 S255 G S I F V W A S G N G G R E G
Chicken Gallus gallus XP_424841 1853 207276 Y496 N P N H H V I Y L E H V V V R
Frog Xenopus laevis P29119 783 86425 V396 R D M Q H L V V Q T S N P A G
Zebra Danio Brachydanio rerio NP_001077298 917 101996 Y509 N A N H H V I Y L E H V V V R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P30432 1679 183351 Y757 G T I N E V R Y L E H V Q C R
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P51559 943 103128 Y535 E S G T P V L Y L E H V Q V H
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P13134 814 89984 D426 V G L E K N A D G D W R D S A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 48.8 42.8 44 N.A. 45.8 45.4 N.A. 46.9 39.4 42.2 70.6 N.A. 29 N.A. 35.7 N.A.
Protein Similarity: 100 49 54.4 45.1 N.A. 47.4 46.7 N.A. 57 43.5 55.5 81.9 N.A. 37.1 N.A. 48 N.A.
P-Site Identity: 100 100 0 93.3 N.A. 93.3 93.3 N.A. 0 86.6 6.6 80 N.A. 46.6 N.A. 46.6 N.A.
P-Site Similarity: 100 100 0 93.3 N.A. 93.3 93.3 N.A. 0 86.6 20 80 N.A. 46.6 N.A. 46.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 28.1 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 44.6 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 0 8 0 16 0 8 0 0 0 8 8 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % C
% Asp: 0 8 0 0 0 0 0 8 0 8 8 0 8 0 0 % D
% Glu: 8 0 0 8 8 0 0 0 0 70 0 0 0 8 0 % E
% Phe: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 16 8 8 0 0 0 0 0 16 0 8 8 0 0 16 % G
% His: 0 0 0 39 62 8 0 0 0 0 70 0 0 0 8 % H
% Ile: 0 0 16 0 0 0 16 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 8 0 8 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 8 0 0 8 16 0 70 0 0 0 0 0 0 % L
% Met: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 54 0 54 8 0 8 39 8 0 16 0 8 0 0 8 % N
% Pro: 0 47 0 8 8 0 0 0 0 0 0 0 8 0 0 % P
% Gln: 0 0 0 8 0 0 0 0 8 0 0 0 16 0 0 % Q
% Arg: 8 0 0 16 0 0 8 0 0 0 0 8 8 0 62 % R
% Ser: 0 24 0 0 0 0 0 8 0 0 8 0 0 8 0 % S
% Thr: 8 8 0 8 0 0 0 0 0 8 0 0 0 8 0 % T
% Val: 8 0 0 0 8 70 8 8 0 0 0 70 54 62 0 % V
% Trp: 0 0 0 0 0 8 0 0 0 0 8 8 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 70 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _