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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PCSK5
All Species:
22.73
Human Site:
Y632
Identified Species:
41.67
UniProt:
Q92824
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92824
NP_006191.2
913
101649
Y632
D
D
Y
G
T
E
D
Y
A
G
P
C
D
P
E
Chimpanzee
Pan troglodytes
XP_520079
1860
206955
Y632
D
D
Y
G
T
E
D
Y
A
G
P
C
D
P
E
Rhesus Macaque
Macaca mulatta
XP_001094068
794
86687
F533
D
G
F
N
D
W
A
F
M
T
T
H
S
W
D
Dog
Lupus familis
XP_541276
1883
209497
Y630
D
D
Y
G
T
E
D
Y
A
G
P
C
D
P
E
Cat
Felis silvestris
Mouse
Mus musculus
Q04592
1877
209270
Y634
D
D
Y
G
A
E
D
Y
A
G
P
C
D
P
E
Rat
Rattus norvegicus
P41413
1877
199778
Y634
D
D
Y
G
A
E
D
Y
A
G
P
C
D
P
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507677
642
72067
K381
K
I
N
G
A
G
R
K
V
S
H
L
Y
G
F
Chicken
Gallus gallus
XP_424841
1853
207276
Y624
E
D
Y
G
T
D
D
Y
S
G
P
C
N
A
E
Frog
Xenopus laevis
P29119
783
86425
S522
A
P
R
P
H
D
Y
S
A
D
G
F
N
D
W
Zebra Danio
Brachydanio rerio
NP_001077298
917
101996
P637
E
Y
V
G
T
C
H
P
E
C
G
E
N
G
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30432
1679
183351
N883
F
L
F
P
S
A
S
N
I
G
Q
P
A
N
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P51559
943
103128
F666
E
E
S
A
R
S
S
F
P
D
L
T
S
G
W
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13134
814
89984
W552
S
S
E
G
F
K
D
W
T
F
M
S
V
A
H
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
48.8
42.8
44
N.A.
45.8
45.4
N.A.
46.9
39.4
42.2
70.6
N.A.
29
N.A.
35.7
N.A.
Protein Similarity:
100
49
54.4
45.1
N.A.
47.4
46.7
N.A.
57
43.5
55.5
81.9
N.A.
37.1
N.A.
48
N.A.
P-Site Identity:
100
100
6.6
100
N.A.
93.3
93.3
N.A.
6.6
66.6
6.6
13.3
N.A.
13.3
N.A.
0
N.A.
P-Site Similarity:
100
100
26.6
100
N.A.
93.3
93.3
N.A.
6.6
93.3
20
26.6
N.A.
26.6
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
28.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
8
24
8
8
0
47
0
0
0
8
16
0
% A
% Cys:
0
0
0
0
0
8
0
0
0
8
0
47
0
0
8
% C
% Asp:
47
47
0
0
8
16
54
0
0
16
0
0
39
8
8
% D
% Glu:
24
8
8
0
0
39
0
0
8
0
0
8
0
0
54
% E
% Phe:
8
0
16
0
8
0
0
16
0
8
0
8
0
0
8
% F
% Gly:
0
8
0
70
0
8
0
0
0
54
16
0
0
24
0
% G
% His:
0
0
0
0
8
0
8
0
0
0
8
8
0
0
8
% H
% Ile:
0
8
0
0
0
0
0
0
8
0
0
0
0
0
0
% I
% Lys:
8
0
0
0
0
8
0
8
0
0
0
0
0
0
0
% K
% Leu:
0
8
0
0
0
0
0
0
0
0
8
8
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
8
0
8
0
0
0
0
% M
% Asn:
0
0
8
8
0
0
0
8
0
0
0
0
24
8
0
% N
% Pro:
0
8
0
16
0
0
0
8
8
0
47
8
0
39
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% Q
% Arg:
0
0
8
0
8
0
8
0
0
0
0
0
0
0
0
% R
% Ser:
8
8
8
0
8
8
16
8
8
8
0
8
16
0
0
% S
% Thr:
0
0
0
0
39
0
0
0
8
8
8
8
0
0
0
% T
% Val:
0
0
8
0
0
0
0
0
8
0
0
0
8
0
0
% V
% Trp:
0
0
0
0
0
8
0
8
0
0
0
0
0
8
16
% W
% Tyr:
0
8
47
0
0
0
8
47
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _