Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PCSK5 All Species: 20.3
Human Site: Y729 Identified Species: 37.22
UniProt: Q92824 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q92824 NP_006191.2 913 101649 Y729 T H C P D G S Y Q D T K K N L
Chimpanzee Pan troglodytes XP_520079 1860 206955 Y729 T H C P D G S Y Q D T K K N L
Rhesus Macaque Macaca mulatta XP_001094068 794 86687 H626 A P Q V L D T H Y S T E N D V
Dog Lupus familis XP_541276 1883 209497 Y727 I H C P D G S Y P D T K K N L
Cat Felis silvestris
Mouse Mus musculus Q04592 1877 209270 Y731 T Q C P D G S Y E D I K K N V
Rat Rattus norvegicus P41413 1877 199778 Y731 A Q C P E G S Y Q D I K K N I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507677 642 72067 S474 Q I H L I S P S G T K S Q L L
Chicken Gallus gallus XP_424841 1853 207276 Y721 T T C P D G F Y L D K N K I V
Frog Xenopus laevis P29119 783 86425 G615 C I K S C P Q G F T S S I Q N
Zebra Danio Brachydanio rerio NP_001077298 917 101996 S733 G F Y L D L E S I M C R K C S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P30432 1679 183351 F1251 V S G C R E G F F V E A G S L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P51559 943 103128 V768 H Y D H G K C V E S C P P G L
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P13134 814 89984 E646 S S I S I G V E T S A I P Q T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 48.8 42.8 44 N.A. 45.8 45.4 N.A. 46.9 39.4 42.2 70.6 N.A. 29 N.A. 35.7 N.A.
Protein Similarity: 100 49 54.4 45.1 N.A. 47.4 46.7 N.A. 57 43.5 55.5 81.9 N.A. 37.1 N.A. 48 N.A.
P-Site Identity: 100 100 6.6 86.6 N.A. 73.3 66.6 N.A. 6.6 53.3 0 13.3 N.A. 6.6 N.A. 6.6 N.A.
P-Site Similarity: 100 100 40 86.6 N.A. 86.6 80 N.A. 13.3 60 6.6 20 N.A. 20 N.A. 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 28.1 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 44.6 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 16 0 0 0 0 0 0 0 0 0 8 8 0 0 0 % A
% Cys: 8 0 47 8 8 0 8 0 0 0 16 0 0 8 0 % C
% Asp: 0 0 8 0 47 8 0 0 0 47 0 0 0 8 0 % D
% Glu: 0 0 0 0 8 8 8 8 16 0 8 8 0 0 0 % E
% Phe: 0 8 0 0 0 0 8 8 16 0 0 0 0 0 0 % F
% Gly: 8 0 8 0 8 54 8 8 8 0 0 0 8 8 0 % G
% His: 8 24 8 8 0 0 0 8 0 0 0 0 0 0 0 % H
% Ile: 8 16 8 0 16 0 0 0 8 0 16 8 8 8 8 % I
% Lys: 0 0 8 0 0 8 0 0 0 0 16 39 54 0 0 % K
% Leu: 0 0 0 16 8 8 0 0 8 0 0 0 0 8 47 % L
% Met: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 8 8 39 8 % N
% Pro: 0 8 0 47 0 8 8 0 8 0 0 8 16 0 0 % P
% Gln: 8 16 8 0 0 0 8 0 24 0 0 0 8 16 0 % Q
% Arg: 0 0 0 0 8 0 0 0 0 0 0 8 0 0 0 % R
% Ser: 8 16 0 16 0 8 39 16 0 24 8 16 0 8 8 % S
% Thr: 31 8 0 0 0 0 8 0 8 16 31 0 0 0 8 % T
% Val: 8 0 0 8 0 0 8 8 0 8 0 0 0 0 24 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 8 0 0 0 0 47 8 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _