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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CASP10 All Species: 4.55
Human Site: T245 Identified Species: 9.09
UniProt: Q92851 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.27
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q92851 NP_001221.2 521 58951 T245 G S N G N R A T N G A P S L V
Chimpanzee Pan troglodytes Q5IS54 277 31588 D34 M D S G I S L D N S Y K M D Y
Rhesus Macaque Macaca mulatta XP_001097804 520 58055 T243 R S N G N R A T D G A P S L V
Dog Lupus familis XP_545593 484 55003 E234 Q F H G A L S E A N V Y R M D
Cat Felis silvestris
Mouse Mus musculus O89110 480 55338 R235 Y Q M K N K P R G Y C L I I N
Rat Rattus norvegicus P55213 277 31473 D34 M D S G I Y L D S S Y K M D Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521249 347 39273 Y104 Y C I I F N N Y T F K G K L N
Chicken Gallus gallus Q98943 424 47941 F181 L I L S N I H F S S E K D L E
Frog Xenopus laevis NP_001083130 512 58781 L240 S G N I D N Q L S D L R L N P
Zebra Danio Brachydanio rerio XP_685430 458 52577 D215 N A S G F S G D N S Q H S D S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O02002 323 35908 V80 M S H K H R G V A L I F N H E
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P42573 503 56598 I247 S P R G M C L I I N N E H F E
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 20.1 75.2 59.5 N.A. 30.3 20.5 N.A. 34.9 22.4 38.5 27.6 N.A. 22.8 N.A. 22 N.A.
Protein Similarity: 100 33.2 82.1 71.4 N.A. 48.3 32.8 N.A. 44.5 39.1 54.8 45.6 N.A. 35.3 N.A. 40.3 N.A.
P-Site Identity: 100 13.3 86.6 6.6 N.A. 6.6 6.6 N.A. 6.6 13.3 6.6 20 N.A. 13.3 N.A. 6.6 N.A.
P-Site Similarity: 100 20 93.3 26.6 N.A. 20 20 N.A. 6.6 20 20 33.3 N.A. 33.3 N.A. 6.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 9 0 0 9 0 17 0 17 0 17 0 0 0 0 % A
% Cys: 0 9 0 0 0 9 0 0 0 0 9 0 0 0 0 % C
% Asp: 0 17 0 0 9 0 0 25 9 9 0 0 9 25 9 % D
% Glu: 0 0 0 0 0 0 0 9 0 0 9 9 0 0 25 % E
% Phe: 0 9 0 0 17 0 0 9 0 9 0 9 0 9 0 % F
% Gly: 9 9 0 59 0 0 17 0 9 17 0 9 0 0 0 % G
% His: 0 0 17 0 9 0 9 0 0 0 0 9 9 9 0 % H
% Ile: 0 9 9 17 17 9 0 9 9 0 9 0 9 9 0 % I
% Lys: 0 0 0 17 0 9 0 0 0 0 9 25 9 0 0 % K
% Leu: 9 0 9 0 0 9 25 9 0 9 9 9 9 34 0 % L
% Met: 25 0 9 0 9 0 0 0 0 0 0 0 17 9 0 % M
% Asn: 9 0 25 0 34 17 9 0 25 17 9 0 9 9 17 % N
% Pro: 0 9 0 0 0 0 9 0 0 0 0 17 0 0 9 % P
% Gln: 9 9 0 0 0 0 9 0 0 0 9 0 0 0 0 % Q
% Arg: 9 0 9 0 0 25 0 9 0 0 0 9 9 0 0 % R
% Ser: 17 25 25 9 0 17 9 0 25 34 0 0 25 0 9 % S
% Thr: 0 0 0 0 0 0 0 17 9 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 9 0 0 9 0 0 0 17 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 17 0 0 0 0 9 0 9 0 9 17 9 0 0 17 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _