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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ARHGEF1
All Species:
11.52
Human Site:
S776
Identified Species:
25.33
UniProt:
Q92888
Number Species:
10
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92888
NP_004697.2
912
102435
S776
S
R
P
K
P
R
P
S
P
S
S
T
R
E
P
Chimpanzee
Pan troglodytes
XP_508820
1441
161918
T1045
P
I
P
L
P
Q
S
T
P
G
E
G
D
N
D
Rhesus Macaque
Macaca mulatta
XP_001116835
1522
167570
P1094
A
A
P
M
P
I
H
P
P
P
P
G
P
Q
E
Dog
Lupus familis
XP_541596
850
95275
Q728
Q
I
Y
E
L
V
A
Q
T
V
S
E
R
K
N
Cat
Felis silvestris
Mouse
Mus musculus
Q61210
920
102786
S775
S
R
L
K
P
R
P
S
P
S
S
I
R
E
P
Rat
Rattus norvegicus
Q9Z1I6
919
102579
S774
S
R
P
K
P
R
P
S
P
S
S
T
R
E
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505606
1628
182548
C1203
P
L
P
Q
S
P
P
C
E
G
E
R
D
E
E
Chicken
Gallus gallus
XP_417890
1614
178830
S1215
R
V
I
P
L
P
Q
S
G
P
G
E
E
E
R
Frog
Xenopus laevis
NP_001082763
1450
164220
D1132
P
A
Q
L
Q
Q
T
D
P
D
L
D
S
E
E
Zebra Danio
Brachydanio rerio
XP_001920310
1422
158610
D1122
I
I
P
L
P
Q
T
D
G
E
R
E
E
V
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_393610
1768
197046
T1420
G
R
R
P
T
P
P
T
T
L
P
E
E
P
G
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
27.8
26.9
75.6
N.A.
87.7
86.8
N.A.
25.3
25.8
26.9
27.7
N.A.
N.A.
22.2
N.A.
N.A.
Protein Similarity:
100
42
40.2
79.3
N.A.
91.6
90.7
N.A.
38.5
38.5
40.6
42.5
N.A.
N.A.
34.1
N.A.
N.A.
P-Site Identity:
100
20
20
13.3
N.A.
86.6
100
N.A.
20
13.3
13.3
13.3
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
100
33.3
33.3
26.6
N.A.
86.6
100
N.A.
26.6
13.3
20
20
N.A.
N.A.
20
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
19
0
0
0
0
10
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
19
0
10
0
10
19
0
10
% D
% Glu:
0
0
0
10
0
0
0
0
10
10
19
37
28
55
37
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
10
0
0
0
0
0
0
0
19
19
10
19
0
0
10
% G
% His:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% H
% Ile:
10
28
10
0
0
10
0
0
0
0
0
10
0
0
0
% I
% Lys:
0
0
0
28
0
0
0
0
0
0
0
0
0
10
0
% K
% Leu:
0
10
10
28
19
0
0
0
0
10
10
0
0
0
0
% L
% Met:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
10
% N
% Pro:
28
0
55
19
55
28
46
10
55
19
19
0
10
10
28
% P
% Gln:
10
0
10
10
10
28
10
10
0
0
0
0
0
10
0
% Q
% Arg:
10
37
10
0
0
28
0
0
0
0
10
10
37
0
10
% R
% Ser:
28
0
0
0
10
0
10
37
0
28
37
0
10
0
0
% S
% Thr:
0
0
0
0
10
0
19
19
19
0
0
19
0
0
0
% T
% Val:
0
10
0
0
0
10
0
0
0
10
0
0
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _