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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ARHGEF1 All Species: 11.52
Human Site: S776 Identified Species: 25.33
UniProt: Q92888 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.2
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q92888 NP_004697.2 912 102435 S776 S R P K P R P S P S S T R E P
Chimpanzee Pan troglodytes XP_508820 1441 161918 T1045 P I P L P Q S T P G E G D N D
Rhesus Macaque Macaca mulatta XP_001116835 1522 167570 P1094 A A P M P I H P P P P G P Q E
Dog Lupus familis XP_541596 850 95275 Q728 Q I Y E L V A Q T V S E R K N
Cat Felis silvestris
Mouse Mus musculus Q61210 920 102786 S775 S R L K P R P S P S S I R E P
Rat Rattus norvegicus Q9Z1I6 919 102579 S774 S R P K P R P S P S S T R E P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505606 1628 182548 C1203 P L P Q S P P C E G E R D E E
Chicken Gallus gallus XP_417890 1614 178830 S1215 R V I P L P Q S G P G E E E R
Frog Xenopus laevis NP_001082763 1450 164220 D1132 P A Q L Q Q T D P D L D S E E
Zebra Danio Brachydanio rerio XP_001920310 1422 158610 D1122 I I P L P Q T D G E R E E V E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_393610 1768 197046 T1420 G R R P T P P T T L P E E P G
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 27.8 26.9 75.6 N.A. 87.7 86.8 N.A. 25.3 25.8 26.9 27.7 N.A. N.A. 22.2 N.A. N.A.
Protein Similarity: 100 42 40.2 79.3 N.A. 91.6 90.7 N.A. 38.5 38.5 40.6 42.5 N.A. N.A. 34.1 N.A. N.A.
P-Site Identity: 100 20 20 13.3 N.A. 86.6 100 N.A. 20 13.3 13.3 13.3 N.A. N.A. 13.3 N.A. N.A.
P-Site Similarity: 100 33.3 33.3 26.6 N.A. 86.6 100 N.A. 26.6 13.3 20 20 N.A. N.A. 20 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 19 0 0 0 0 10 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 19 0 10 0 10 19 0 10 % D
% Glu: 0 0 0 10 0 0 0 0 10 10 19 37 28 55 37 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 10 0 0 0 0 0 0 0 19 19 10 19 0 0 10 % G
% His: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % H
% Ile: 10 28 10 0 0 10 0 0 0 0 0 10 0 0 0 % I
% Lys: 0 0 0 28 0 0 0 0 0 0 0 0 0 10 0 % K
% Leu: 0 10 10 28 19 0 0 0 0 10 10 0 0 0 0 % L
% Met: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 10 % N
% Pro: 28 0 55 19 55 28 46 10 55 19 19 0 10 10 28 % P
% Gln: 10 0 10 10 10 28 10 10 0 0 0 0 0 10 0 % Q
% Arg: 10 37 10 0 0 28 0 0 0 0 10 10 37 0 10 % R
% Ser: 28 0 0 0 10 0 10 37 0 28 37 0 10 0 0 % S
% Thr: 0 0 0 0 10 0 19 19 19 0 0 19 0 0 0 % T
% Val: 0 10 0 0 0 10 0 0 0 10 0 0 0 10 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _