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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ARHGEF1
All Species:
3.64
Human Site:
T321
Identified Species:
8
UniProt:
Q92888
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92888
NP_004697.2
912
102435
T321
I
G
A
P
G
Q
D
T
P
G
V
S
L
H
P
Chimpanzee
Pan troglodytes
XP_508820
1441
161918
S562
A
G
Y
L
P
A
N
S
M
S
S
V
A
S
G
Rhesus Macaque
Macaca mulatta
XP_001116835
1522
167570
R608
D
S
S
R
S
E
I
R
L
G
R
S
E
S
L
Dog
Lupus familis
XP_541596
850
95275
L304
T
E
R
R
W
K
R
L
S
G
R
L
G
R
S
Cat
Felis silvestris
Mouse
Mus musculus
Q61210
920
102786
N319
V
G
T
P
G
Q
D
N
P
G
V
S
L
H
P
Rat
Rattus norvegicus
Q9Z1I6
919
102579
N318
V
G
T
P
G
Q
D
N
P
G
V
S
L
H
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505606
1628
182548
P720
V
G
Y
L
P
A
N
P
T
S
S
L
T
S
G
Chicken
Gallus gallus
XP_417890
1614
178830
M734
P
Y
P
P
A
N
P
M
S
P
L
A
V
G
P
Frog
Xenopus laevis
NP_001082763
1450
164220
S637
D
G
S
R
L
R
T
S
G
G
S
I
E
G
S
Zebra Danio
Brachydanio rerio
XP_001920310
1422
158610
A631
E
G
S
D
G
T
N
A
L
I
T
S
P
P
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_393610
1768
197046
Y914
E
R
G
R
I
S
A
Y
S
G
V
S
D
H
A
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
27.8
26.9
75.6
N.A.
87.7
86.8
N.A.
25.3
25.8
26.9
27.7
N.A.
N.A.
22.2
N.A.
N.A.
Protein Similarity:
100
42
40.2
79.3
N.A.
91.6
90.7
N.A.
38.5
38.5
40.6
42.5
N.A.
N.A.
34.1
N.A.
N.A.
P-Site Identity:
100
6.6
13.3
6.6
N.A.
80
80
N.A.
6.6
13.3
13.3
20
N.A.
N.A.
26.6
N.A.
N.A.
P-Site Similarity:
100
20
26.6
13.3
N.A.
86.6
86.6
N.A.
20
33.3
33.3
33.3
N.A.
N.A.
26.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
10
0
10
19
10
10
0
0
0
10
10
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
19
0
0
10
0
0
28
0
0
0
0
0
10
0
0
% D
% Glu:
19
10
0
0
0
10
0
0
0
0
0
0
19
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
64
10
0
37
0
0
0
10
64
0
0
10
19
19
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
37
0
% H
% Ile:
10
0
0
0
10
0
10
0
0
10
0
10
0
0
0
% I
% Lys:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
19
10
0
0
10
19
0
10
19
28
0
10
% L
% Met:
0
0
0
0
0
0
0
10
10
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
10
28
19
0
0
0
0
0
0
0
% N
% Pro:
10
0
10
37
19
0
10
10
28
10
0
0
10
10
37
% P
% Gln:
0
0
0
0
0
28
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
10
10
37
0
10
10
10
0
0
19
0
0
10
0
% R
% Ser:
0
10
28
0
10
10
0
19
28
19
28
55
0
28
19
% S
% Thr:
10
0
19
0
0
10
10
10
10
0
10
0
10
0
0
% T
% Val:
28
0
0
0
0
0
0
0
0
0
37
10
10
0
0
% V
% Trp:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
10
19
0
0
0
0
10
0
0
0
0
0
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _