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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ERCC4
All Species:
12.12
Human Site:
S458
Identified Species:
22.22
UniProt:
Q92889
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92889
NP_005227.1
916
104486
S458
M
K
F
R
K
E
D
S
S
K
R
I
R
K
S
Chimpanzee
Pan troglodytes
XP_510831
916
104478
S458
M
K
F
R
K
E
D
S
S
K
R
I
R
K
P
Rhesus Macaque
Macaca mulatta
XP_001107209
916
104412
S458
M
K
F
R
K
E
D
S
S
K
R
I
R
K
S
Dog
Lupus familis
XP_536967
917
104078
S459
M
K
L
R
H
E
D
S
P
K
R
M
A
R
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9QZD4
917
103672
G458
V
N
V
R
K
G
D
G
P
K
R
T
T
K
S
Rat
Rattus norvegicus
XP_222534
917
103888
G458
V
N
F
R
K
G
D
G
P
K
R
T
M
K
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505617
688
78099
D244
K
T
I
R
H
Y
L
D
P
L
W
H
Q
L
G
Chicken
Gallus gallus
XP_414734
904
103087
K447
I
K
D
R
K
V
V
K
S
K
G
N
A
R
P
Frog
Xenopus laevis
NP_001086576
897
102089
K443
I
K
S
R
K
A
M
K
A
K
G
N
N
K
S
Zebra Danio
Brachydanio rerio
NP_956079
886
101028
L436
E
D
P
Q
P
D
L
L
K
L
D
K
G
W
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24087
961
109500
G479
L
R
R
E
E
V
S
G
S
Q
P
P
L
A
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LKI5
956
107616
E447
P
Q
K
V
M
R
E
E
W
E
M
Y
L
L
S
Baker's Yeast
Sacchar. cerevisiae
P06777
1100
126352
V568
S
T
F
S
K
E
Q
V
T
T
K
R
R
R
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
97.3
90.8
N.A.
86
86.8
N.A.
55.7
68.8
73.4
62.9
N.A.
39.1
N.A.
N.A.
N.A.
Protein Similarity:
100
99.7
98.4
94.9
N.A.
92.3
92.8
N.A.
64.5
78.4
85.1
78.2
N.A.
60
N.A.
N.A.
N.A.
P-Site Identity:
100
93.3
100
60
N.A.
46.6
53.3
N.A.
6.6
33.3
40
0
N.A.
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
93.3
100
73.3
N.A.
53.3
60
N.A.
13.3
46.6
53.3
13.3
N.A.
33.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
36.5
28
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
56.3
45.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
8
0
0
8
0
0
0
16
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
8
0
0
8
47
8
0
0
8
0
0
0
0
% D
% Glu:
8
0
0
8
8
39
8
8
0
8
0
0
0
0
0
% E
% Phe:
0
0
39
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
16
0
24
0
0
16
0
8
0
16
% G
% His:
0
0
0
0
16
0
0
0
0
0
0
8
0
0
0
% H
% Ile:
16
0
8
0
0
0
0
0
0
0
0
24
0
0
0
% I
% Lys:
8
47
8
0
62
0
0
16
8
62
8
8
0
47
0
% K
% Leu:
8
0
8
0
0
0
16
8
0
16
0
0
16
16
0
% L
% Met:
31
0
0
0
8
0
8
0
0
0
8
8
8
0
0
% M
% Asn:
0
16
0
0
0
0
0
0
0
0
0
16
8
0
0
% N
% Pro:
8
0
8
0
8
0
0
0
31
0
8
8
0
0
16
% P
% Gln:
0
8
0
8
0
0
8
0
0
8
0
0
8
0
8
% Q
% Arg:
0
8
8
70
0
8
0
0
0
0
47
8
31
24
0
% R
% Ser:
8
0
8
8
0
0
8
31
39
0
0
0
0
0
54
% S
% Thr:
0
16
0
0
0
0
0
0
8
8
0
16
8
0
8
% T
% Val:
16
0
8
8
0
16
8
8
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
8
0
8
0
0
8
0
% W
% Tyr:
0
0
0
0
0
8
0
0
0
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _