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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ERCC4
All Species:
16.06
Human Site:
S520
Identified Species:
29.44
UniProt:
Q92889
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92889
NP_005227.1
916
104486
S520
G
Y
R
R
E
I
S
S
S
P
E
S
C
P
E
Chimpanzee
Pan troglodytes
XP_510831
916
104478
S520
G
Y
R
R
E
I
S
S
S
P
E
S
C
P
E
Rhesus Macaque
Macaca mulatta
XP_001107209
916
104412
S520
G
Y
C
R
E
I
S
S
S
P
E
S
C
L
E
Dog
Lupus familis
XP_536967
917
104078
S521
G
Y
P
R
D
T
G
S
S
P
E
S
S
L
E
Cat
Felis silvestris
Mouse
Mus musculus
Q9QZD4
917
103672
S521
D
L
C
R
Q
T
S
S
S
P
E
G
C
G
V
Rat
Rattus norvegicus
XP_222534
917
103888
S521
D
L
H
K
Q
T
G
S
S
P
E
V
C
G
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505617
688
78099
L302
Q
N
S
G
W
L
F
L
D
S
S
T
S
M
F
Chicken
Gallus gallus
XP_414734
904
103087
G507
E
D
N
K
E
L
N
G
S
Q
E
G
S
I
E
Frog
Xenopus laevis
NP_001086576
897
102089
M502
E
T
Y
G
E
E
S
M
S
Q
E
S
S
I
E
Zebra Danio
Brachydanio rerio
NP_956079
886
101028
G494
N
E
N
S
E
D
E
G
G
L
I
E
E
E
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24087
961
109500
I537
D
V
S
I
F
E
T
I
P
E
L
E
Q
F
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LKI5
956
107616
K562
N
K
K
T
T
N
S
K
P
E
I
L
P
G
P
Baker's Yeast
Sacchar. cerevisiae
P06777
1100
126352
E654
D
A
E
F
D
N
G
E
L
E
Y
V
G
D
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
97.3
90.8
N.A.
86
86.8
N.A.
55.7
68.8
73.4
62.9
N.A.
39.1
N.A.
N.A.
N.A.
Protein Similarity:
100
99.7
98.4
94.9
N.A.
92.3
92.8
N.A.
64.5
78.4
85.1
78.2
N.A.
60
N.A.
N.A.
N.A.
P-Site Identity:
100
100
86.6
60
N.A.
46.6
33.3
N.A.
0
26.6
40
13.3
N.A.
0
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
86.6
66.6
N.A.
53.3
46.6
N.A.
13.3
46.6
40
13.3
N.A.
13.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
36.5
28
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
56.3
45.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
16
0
0
0
0
0
0
0
0
0
39
0
0
% C
% Asp:
31
8
0
0
16
8
0
0
8
0
0
0
0
8
8
% D
% Glu:
16
8
8
0
47
16
8
8
0
24
62
16
8
8
54
% E
% Phe:
0
0
0
8
8
0
8
0
0
0
0
0
0
8
8
% F
% Gly:
31
0
0
16
0
0
24
16
8
0
0
16
8
24
8
% G
% His:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
8
0
24
0
8
0
0
16
0
0
16
0
% I
% Lys:
0
8
8
16
0
0
0
8
0
0
0
0
0
0
0
% K
% Leu:
0
16
0
0
0
16
0
8
8
8
8
8
0
16
8
% L
% Met:
0
0
0
0
0
0
0
8
0
0
0
0
0
8
0
% M
% Asn:
16
8
16
0
0
16
8
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
8
0
0
0
0
0
16
47
0
0
8
16
8
% P
% Gln:
8
0
0
0
16
0
0
0
0
16
0
0
8
0
0
% Q
% Arg:
0
0
16
39
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
16
8
0
0
47
47
62
8
8
39
31
0
0
% S
% Thr:
0
8
0
8
8
24
8
0
0
0
0
8
0
0
0
% T
% Val:
0
8
0
0
0
0
0
0
0
0
0
16
0
0
8
% V
% Trp:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
31
8
0
0
0
0
0
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _