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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ERCC4 All Species: 35.15
Human Site: Y577 Identified Species: 64.44
UniProt: Q92889 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q92889 NP_005227.1 916 104486 Y577 L H E V E P R Y V V L Y D A E
Chimpanzee Pan troglodytes XP_510831 916 104478 Y577 L H E V E P R Y V V L Y D A E
Rhesus Macaque Macaca mulatta XP_001107209 916 104412 Y577 L H E V E P R Y V V L Y D A E
Dog Lupus familis XP_536967 917 104078 Y578 L H E V E P R Y V V L Y D A E
Cat Felis silvestris
Mouse Mus musculus Q9QZD4 917 103672 Y578 L H E V E P R Y V V L Y D A E
Rat Rattus norvegicus XP_222534 917 103888 Y578 L H E V E P R Y V V L Y D A E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505617 688 78099 E359 P K W E A L T E V L K E I E I
Chicken Gallus gallus XP_414734 904 103087 Y564 L H E V E P R Y V V L Y D A E
Frog Xenopus laevis NP_001086576 897 102089 Y559 L H E I E P R Y V V L Y D S E
Zebra Danio Brachydanio rerio NP_956079 886 101028 L551 V D P M F V V L Y D A E L S F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24087 961 109500 A594 M Y N M N V T A I R Q L E V F
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LKI5 956 107616 V619 L D I L K P S V I I V Y H P D
Baker's Yeast Sacchar. cerevisiae P06777 1100 126352 Y711 L Q E M M P S Y I I M F E P D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 97.3 90.8 N.A. 86 86.8 N.A. 55.7 68.8 73.4 62.9 N.A. 39.1 N.A. N.A. N.A.
Protein Similarity: 100 99.7 98.4 94.9 N.A. 92.3 92.8 N.A. 64.5 78.4 85.1 78.2 N.A. 60 N.A. N.A. N.A.
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 6.6 100 86.6 0 N.A. 0 N.A. N.A. N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 13.3 100 100 20 N.A. 33.3 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 36.5 28 N.A.
Protein Similarity: N.A. N.A. N.A. 56.3 45.6 N.A.
P-Site Identity: N.A. N.A. N.A. 20 26.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 60 73.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 8 0 0 8 0 0 8 0 0 54 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 16 0 0 0 0 0 0 0 8 0 0 62 0 16 % D
% Glu: 0 0 70 8 62 0 0 8 0 0 0 16 16 8 62 % E
% Phe: 0 0 0 0 8 0 0 0 0 0 0 8 0 0 16 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 62 0 0 0 0 0 0 0 0 0 0 8 0 0 % H
% Ile: 0 0 8 8 0 0 0 0 24 16 0 0 8 0 8 % I
% Lys: 0 8 0 0 8 0 0 0 0 0 8 0 0 0 0 % K
% Leu: 77 0 0 8 0 8 0 8 0 8 62 8 8 0 0 % L
% Met: 8 0 0 24 8 0 0 0 0 0 8 0 0 0 0 % M
% Asn: 0 0 8 0 8 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 8 0 8 0 0 77 0 0 0 0 0 0 0 16 0 % P
% Gln: 0 8 0 0 0 0 0 0 0 0 8 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 62 0 0 8 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 16 0 0 0 0 0 0 16 0 % S
% Thr: 0 0 0 0 0 0 16 0 0 0 0 0 0 0 0 % T
% Val: 8 0 0 54 0 16 8 8 70 62 8 0 0 8 0 % V
% Trp: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 0 0 0 0 0 70 8 0 0 70 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _