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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: UFD1L All Species: 23.33
Human Site: S245 Identified Species: 46.67
UniProt: Q92890 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q92890 NP_005650.2 307 34500 S245 K K K G V E P S P S P I K P G
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001104799 307 34424 S245 K K K G V E P S P S P I K P G
Dog Lupus familis XP_850373 499 55148 T324 L L P C H L G T S A E I X L C
Cat Felis silvestris
Mouse Mus musculus P70362 307 34466 S245 K K K G V E P S P S P I K P G
Rat Rattus norvegicus Q9ES53 307 34467 S245 K K K G V E P S P S P I K P G
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_989632 307 34544 S245 K K K G V E P S P S P I K P G
Frog Xenopus laevis NP_001083638 307 34839 S245 K K K G I D P S P S P L K P E
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VTF9 316 34773 L250 K K K K E S Q L E T P V V K K
Honey Bee Apis mellifera XP_396320 298 34112 P241 K R R D F A K P E V T T N K P
Nematode Worm Caenorhab. elegans Q19584 342 36886 A276 G V S T S N A A P V A N D L P
Sea Urchin Strong. purpuratus XP_784491 308 35058 K245 K K K N V D Y K P V I P P E D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P53044 361 39792 N249 I D Y A G I A N S S R N K L S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 99.6 51.9 N.A. 98.3 98.6 N.A. N.A. 94.7 91.2 N.A. N.A. 57.9 58.9 37.7 61.3
Protein Similarity: 100 N.A. 99.6 54.7 N.A. 99.3 99.3 N.A. N.A. 98 95.4 N.A. N.A. 69.3 73.2 53.7 73.7
P-Site Identity: 100 N.A. 100 6.6 N.A. 100 100 N.A. N.A. 100 73.3 N.A. N.A. 26.6 6.6 6.6 33.3
P-Site Similarity: 100 N.A. 100 20 N.A. 100 100 N.A. N.A. 100 93.3 N.A. N.A. 40 20 13.3 40
Percent
Protein Identity: N.A. N.A. N.A. N.A. 37.6 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 54 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 9 0 9 17 9 0 9 9 0 0 0 0 % A
% Cys: 0 0 0 9 0 0 0 0 0 0 0 0 0 0 9 % C
% Asp: 0 9 0 9 0 17 0 0 0 0 0 0 9 0 9 % D
% Glu: 0 0 0 0 9 42 0 0 17 0 9 0 0 9 9 % E
% Phe: 0 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 9 0 0 50 9 0 9 0 0 0 0 0 0 0 42 % G
% His: 0 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 9 0 0 0 9 9 0 0 0 0 9 50 0 0 0 % I
% Lys: 75 67 67 9 0 0 9 9 0 0 0 0 59 17 9 % K
% Leu: 9 9 0 0 0 9 0 9 0 0 0 9 0 25 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 9 0 9 0 9 0 0 0 17 9 0 0 % N
% Pro: 0 0 9 0 0 0 50 9 67 0 59 9 9 50 17 % P
% Gln: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % Q
% Arg: 0 9 9 0 0 0 0 0 0 0 9 0 0 0 0 % R
% Ser: 0 0 9 0 9 9 0 50 17 59 0 0 0 0 9 % S
% Thr: 0 0 0 9 0 0 0 9 0 9 9 9 0 0 0 % T
% Val: 0 9 0 0 50 0 0 0 0 25 0 9 9 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 9 0 0 0 9 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _