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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: UPF1 All Species: 20.3
Human Site: S1052 Identified Species: 34.36
UniProt: Q92900 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q92900 NP_002902.2 1129 124345 S1052 N L P N S Q A S Q D V A S Q P
Chimpanzee Pan troglodytes XP_512972 974 107722 L898 Y Y K E Q K V L V E G P L N N
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_533868 1119 123129 S1042 N L P N S Q A S Q D V A S Q P
Cat Felis silvestris
Mouse Mus musculus Q9EPU0 1124 123948 S1047 T L P N S Q A S Q D V A S Q P
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514946 1113 122992 S1037 N I P N S Q A S Q D V V S Q P
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres Q98TR3 1097 122320 P1020 H A K Q S D Q P G W G F P V I
Fruit Fly Dros. melanogaster Q9VYS3 1180 129895 G1077 G P G V T G V G V G R S A T P
Honey Bee Apis mellifera XP_393330 1119 125484 N1036 K L S Q T E Q N T Q P Y S Q P
Nematode Worm Caenorhab. elegans O76512 1069 120001 L990 Q A E A A M D L S Q G M M S Q
Sea Urchin Strong. purpuratus XP_786803 1157 128015 S1071 S L N S T Q N S Q P D V S Q S
Poplar Tree Populus trichocarpa XP_002329539 1242 136050 S1103 D D F K S Q G S H V P Y N V A
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FJR0 1254 136850 S1117 D D I K S Q G S H D P Y N M A
Baker's Yeast Sacchar. cerevisiae P30771 971 109412 F895 F S G Q I G D F G N A F V D N
Red Bread Mold Neurospora crassa Q9HEH1 1093 120070 S1017 S E F T D A T S S V I G G K G
Conservation
Percent
Protein Identity: 100 85.3 N.A. 98.7 N.A. 98.4 N.A. N.A. 96.6 N.A. N.A. N.A. 86 62.4 70.2 47.6 71.5
Protein Similarity: 100 85.6 N.A. 98.9 N.A. 99.1 N.A. N.A. 97.3 N.A. N.A. N.A. 89 73.7 80.5 62.6 81.3
P-Site Identity: 100 0 N.A. 100 N.A. 93.3 N.A. N.A. 86.6 N.A. N.A. N.A. 6.6 6.6 26.6 0 40
P-Site Similarity: 100 13.3 N.A. 100 N.A. 93.3 N.A. N.A. 93.3 N.A. N.A. N.A. 13.3 26.6 46.6 6.6 60
Percent
Protein Identity: 55.7 N.A. N.A. 55.2 45.4 52.7
Protein Similarity: 67.3 N.A. N.A. 67.4 61.3 67.6
P-Site Identity: 20 N.A. N.A. 26.6 0 6.6
P-Site Similarity: 33.3 N.A. N.A. 40 6.6 26.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 15 0 8 8 8 29 0 0 0 8 22 8 0 15 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 15 15 0 0 8 8 15 0 0 36 8 0 0 8 0 % D
% Glu: 0 8 8 8 0 8 0 0 0 8 0 0 0 0 0 % E
% Phe: 8 0 15 0 0 0 0 8 0 0 0 15 0 0 0 % F
% Gly: 8 0 15 0 0 15 15 8 15 8 22 8 8 0 8 % G
% His: 8 0 0 0 0 0 0 0 15 0 0 0 0 0 0 % H
% Ile: 0 8 8 0 8 0 0 0 0 0 8 0 0 0 8 % I
% Lys: 8 0 15 15 0 8 0 0 0 0 0 0 0 8 0 % K
% Leu: 0 36 0 0 0 0 0 15 0 0 0 0 8 0 0 % L
% Met: 0 0 0 0 0 8 0 0 0 0 0 8 8 8 0 % M
% Asn: 22 0 8 29 0 0 8 8 0 8 0 0 15 8 15 % N
% Pro: 0 8 29 0 0 0 0 8 0 8 22 8 8 0 43 % P
% Gln: 8 0 0 22 8 50 15 0 36 15 0 0 0 43 8 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % R
% Ser: 15 8 8 8 50 0 0 58 15 0 0 8 43 8 8 % S
% Thr: 8 0 0 8 22 0 8 0 8 0 0 0 0 8 0 % T
% Val: 0 0 0 8 0 0 15 0 15 15 29 15 8 15 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % W
% Tyr: 8 8 0 0 0 0 0 0 0 0 0 22 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _