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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: UPF1 All Species: 35.45
Human Site: S568 Identified Species: 60
UniProt: Q92900 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q92900 NP_002902.2 1129 124345 S568 E A I D S P V S F L A L H N Q
Chimpanzee Pan troglodytes XP_512972 974 107722 N472 A Q G L P D L N H S Q V Y A V
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_533868 1119 123129 S558 E A I D S P V S F L A L H N Q
Cat Felis silvestris
Mouse Mus musculus Q9EPU0 1124 123948 S563 E A I D S P V S F L A L H N Q
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514946 1113 122992 S554 E A I D S P V S F L A L H N Q
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres Q98TR3 1097 122320 S539 E A I E S P V S F L A L H N Q
Fruit Fly Dros. melanogaster Q9VYS3 1180 129895 S538 E A I D S P V S F L A L H N Q
Honey Bee Apis mellifera XP_393330 1119 125484 S541 E A I D S P V S F L A L H N Q
Nematode Worm Caenorhab. elegans O76512 1069 120001 P532 E H S E T T V P Y L T L Q H Q
Sea Urchin Strong. purpuratus XP_786803 1157 128015 S544 E A I D S P V S F L S L H N Q
Poplar Tree Populus trichocarpa XP_002329539 1242 136050 E570 E A V S S P V E H L T L H Y Q
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FJR0 1254 136850 E575 E A V S S P V E Y L T L H Y Q
Baker's Yeast Sacchar. cerevisiae P30771 971 109412 A469 N V A V D H L A A K L R D L G
Red Bread Mold Neurospora crassa Q9HEH1 1093 120070 S542 E D V E S S V S F L A L H E Q
Conservation
Percent
Protein Identity: 100 85.3 N.A. 98.7 N.A. 98.4 N.A. N.A. 96.6 N.A. N.A. N.A. 86 62.4 70.2 47.6 71.5
Protein Similarity: 100 85.6 N.A. 98.9 N.A. 99.1 N.A. N.A. 97.3 N.A. N.A. N.A. 89 73.7 80.5 62.6 81.3
P-Site Identity: 100 0 N.A. 100 N.A. 100 N.A. N.A. 100 N.A. N.A. N.A. 93.3 100 100 33.3 93.3
P-Site Similarity: 100 26.6 N.A. 100 N.A. 100 N.A. N.A. 100 N.A. N.A. N.A. 100 100 100 60 100
Percent
Protein Identity: 55.7 N.A. N.A. 55.2 45.4 52.7
Protein Similarity: 67.3 N.A. N.A. 67.4 61.3 67.6
P-Site Identity: 60 N.A. N.A. 60 0 66.6
P-Site Similarity: 66.6 N.A. N.A. 73.3 13.3 80
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 72 8 0 0 0 0 8 8 0 58 0 0 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 8 0 50 8 8 0 0 0 0 0 0 8 0 0 % D
% Glu: 86 0 0 22 0 0 0 15 0 0 0 0 0 8 0 % E
% Phe: 0 0 0 0 0 0 0 0 65 0 0 0 0 0 0 % F
% Gly: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 8 % G
% His: 0 8 0 0 0 8 0 0 15 0 0 0 79 8 0 % H
% Ile: 0 0 58 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % K
% Leu: 0 0 0 8 0 0 15 0 0 86 8 86 0 8 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 8 0 0 0 0 0 0 8 0 0 0 0 0 58 0 % N
% Pro: 0 0 0 0 8 72 0 8 0 0 0 0 0 0 0 % P
% Gln: 0 8 0 0 0 0 0 0 0 0 8 0 8 0 86 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % R
% Ser: 0 0 8 15 79 8 0 65 0 8 8 0 0 0 0 % S
% Thr: 0 0 0 0 8 8 0 0 0 0 22 0 0 0 0 % T
% Val: 0 8 22 8 0 0 86 0 0 0 0 8 0 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 15 0 0 0 8 15 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _