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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: UPF1 All Species: 18.18
Human Site: S925 Identified Species: 30.77
UniProt: Q92900 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q92900 NP_002902.2 1129 124345 S925 R E S L M Q F S K P R K L V N
Chimpanzee Pan troglodytes XP_512972 974 107722 L780 V E K I T T K L L K A G A K P
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_533868 1119 123129 S915 R E S L M Q F S K P R K L V N
Cat Felis silvestris
Mouse Mus musculus Q9EPU0 1124 123948 S920 R E S L M Q F S K P R K L V N
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514946 1113 122992 S911 R E S L M Q F S K P R K L V N
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres Q98TR3 1097 122320 F893 L R E S L M Q F S K P R K L V
Fruit Fly Dros. melanogaster Q9VYS3 1180 129895 Q894 K E S L I H F Q K P K K L V N
Honey Bee Apis mellifera XP_393330 1119 125484 A898 K E S M I Q F A K P K K L V N
Nematode Worm Caenorhab. elegans O76512 1069 120001 M871 N H Y K S K E M L Y E G P I N
Sea Urchin Strong. purpuratus XP_786803 1157 128015 S901 K E S L I Q F S K P R K L I N
Poplar Tree Populus trichocarpa XP_002329539 1242 136050 Q929 K Q S M V Q F Q K P K K I Y N
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FJR0 1254 136850 Q934 K Q S M V Q F Q K P R K I Y N
Baker's Yeast Sacchar. cerevisiae P30771 971 109412 C777 K D Y I I L S C V R A N E Q Q
Red Bread Mold Neurospora crassa Q9HEH1 1093 120070 G899 Q P S L L Q F G R P R Q A Y R
Conservation
Percent
Protein Identity: 100 85.3 N.A. 98.7 N.A. 98.4 N.A. N.A. 96.6 N.A. N.A. N.A. 86 62.4 70.2 47.6 71.5
Protein Similarity: 100 85.6 N.A. 98.9 N.A. 99.1 N.A. N.A. 97.3 N.A. N.A. N.A. 89 73.7 80.5 62.6 81.3
P-Site Identity: 100 6.6 N.A. 100 N.A. 100 N.A. N.A. 100 N.A. N.A. N.A. 0 66.6 66.6 6.6 80
P-Site Similarity: 100 13.3 N.A. 100 N.A. 100 N.A. N.A. 100 N.A. N.A. N.A. 20 86.6 100 20 100
Percent
Protein Identity: 55.7 N.A. N.A. 55.2 45.4 52.7
Protein Similarity: 67.3 N.A. N.A. 67.4 61.3 67.6
P-Site Identity: 46.6 N.A. N.A. 53.3 0 40
P-Site Similarity: 86.6 N.A. N.A. 86.6 26.6 66.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 8 0 0 15 0 15 0 0 % A
% Cys: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % C
% Asp: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 58 8 0 0 0 8 0 0 0 8 0 8 0 0 % E
% Phe: 0 0 0 0 0 0 72 8 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 8 0 0 0 15 0 0 0 % G
% His: 0 8 0 0 0 8 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 15 29 0 0 0 0 0 0 0 15 15 0 % I
% Lys: 43 0 8 8 0 8 8 0 65 15 22 65 8 8 0 % K
% Leu: 8 0 0 50 15 8 0 8 15 0 0 0 50 8 0 % L
% Met: 0 0 0 22 29 8 0 8 0 0 0 0 0 0 0 % M
% Asn: 8 0 0 0 0 0 0 0 0 0 0 8 0 0 72 % N
% Pro: 0 8 0 0 0 0 0 0 0 72 8 0 8 0 8 % P
% Gln: 8 15 0 0 0 65 8 22 0 0 0 8 0 8 8 % Q
% Arg: 29 8 0 0 0 0 0 0 8 8 50 8 0 0 8 % R
% Ser: 0 0 72 8 8 0 8 36 8 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 8 8 0 0 0 0 0 0 0 0 0 % T
% Val: 8 0 0 0 15 0 0 0 8 0 0 0 0 43 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 15 0 0 0 0 0 0 8 0 0 0 22 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _