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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: UPF1 All Species: 21.21
Human Site: S956 Identified Species: 35.9
UniProt: Q92900 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q92900 NP_002902.2 1129 124345 S956 R E A I I P G S V Y D R S S Q
Chimpanzee Pan troglodytes XP_512972 974 107722 G811 V Q Y M Q F S G S L H T K L Y
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_533868 1119 123129 S946 R E A I I P G S V Y D R S S Q
Cat Felis silvestris
Mouse Mus musculus Q9EPU0 1124 123948 S951 R E A I I P G S V Y D R S S Q
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514946 1113 122992 S942 R E A I I P G S V Y D R S S Q
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres Q98TR3 1097 122320 A924 E A L I P G S A Y D R S N T G
Fruit Fly Dros. melanogaster Q9VYS3 1180 129895 S925 K E V M V P G S I Y D R S G G
Honey Bee Apis mellifera XP_393330 1119 125484 S929 R E A L I P G S V Y D R S G T
Nematode Worm Caenorhab. elegans O76512 1069 120001 A902 K N N I A G N A N R F G I K R
Sea Urchin Strong. purpuratus XP_786803 1157 128015 G932 R E A L A P G G V F D R S R M
Poplar Tree Populus trichocarpa XP_002329539 1242 136050 A960 S F G S V A S A S S N A D R R
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FJR0 1254 136850 N965 N F G S G N P N A D R R G S R
Baker's Yeast Sacchar. cerevisiae P30771 971 109412 I808 R A K Y G L V I L G N P R S L
Red Bread Mold Neurospora crassa Q9HEH1 1093 120070 A930 R F A A P L T A G S V R D Y E
Conservation
Percent
Protein Identity: 100 85.3 N.A. 98.7 N.A. 98.4 N.A. N.A. 96.6 N.A. N.A. N.A. 86 62.4 70.2 47.6 71.5
Protein Similarity: 100 85.6 N.A. 98.9 N.A. 99.1 N.A. N.A. 97.3 N.A. N.A. N.A. 89 73.7 80.5 62.6 81.3
P-Site Identity: 100 0 N.A. 100 N.A. 100 N.A. N.A. 100 N.A. N.A. N.A. 6.6 53.3 80 6.6 60
P-Site Similarity: 100 13.3 N.A. 100 N.A. 100 N.A. N.A. 100 N.A. N.A. N.A. 26.6 80 86.6 26.6 73.3
Percent
Protein Identity: 55.7 N.A. N.A. 55.2 45.4 52.7
Protein Similarity: 67.3 N.A. N.A. 67.4 61.3 67.6
P-Site Identity: 0 N.A. N.A. 13.3 13.3 20
P-Site Similarity: 26.6 N.A. N.A. 26.6 26.6 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 15 50 8 15 8 0 29 8 0 0 8 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 15 50 0 15 0 0 % D
% Glu: 8 50 0 0 0 0 0 0 0 0 0 0 0 0 8 % E
% Phe: 0 22 0 0 0 8 0 0 0 8 8 0 0 0 0 % F
% Gly: 0 0 15 0 15 15 50 15 8 8 0 8 8 15 15 % G
% His: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % H
% Ile: 0 0 0 43 36 0 0 8 8 0 0 0 8 0 0 % I
% Lys: 15 0 8 0 0 0 0 0 0 0 0 0 8 8 0 % K
% Leu: 0 0 8 15 0 15 0 0 8 8 0 0 0 8 8 % L
% Met: 0 0 0 15 0 0 0 0 0 0 0 0 0 0 8 % M
% Asn: 8 8 8 0 0 8 8 8 8 0 15 0 8 0 0 % N
% Pro: 0 0 0 0 15 50 8 0 0 0 0 8 0 0 0 % P
% Gln: 0 8 0 0 8 0 0 0 0 0 0 0 0 0 29 % Q
% Arg: 58 0 0 0 0 0 0 0 0 8 15 65 8 15 22 % R
% Ser: 8 0 0 15 0 0 22 43 15 15 0 8 50 43 0 % S
% Thr: 0 0 0 0 0 0 8 0 0 0 0 8 0 8 8 % T
% Val: 8 0 8 0 15 0 8 0 43 0 8 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 8 8 0 0 0 0 8 43 0 0 0 8 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _