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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: UPF1 All Species: 20.91
Human Site: S961 Identified Species: 35.38
UniProt: Q92900 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q92900 NP_002902.2 1129 124345 S961 P G S V Y D R S S Q G R P S S
Chimpanzee Pan troglodytes XP_512972 974 107722 K816 F S G S L H T K L Y Q E V E I
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_533868 1119 123129 S951 P G S V Y D R S S Q G R P S N
Cat Felis silvestris
Mouse Mus musculus Q9EPU0 1124 123948 S956 P G S V Y D R S S Q G R P S N
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514946 1113 122992 S947 P G S V Y D R S S Q G R P S N
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres Q98TR3 1097 122320 N929 G S A Y D R S N T G G R P S N
Fruit Fly Dros. melanogaster Q9VYS3 1180 129895 S930 P G S I Y D R S G G Y G Q G R
Honey Bee Apis mellifera XP_393330 1119 125484 S934 P G S V Y D R S G T Q V N G T
Nematode Worm Caenorhab. elegans O76512 1069 120001 I907 G N A N R F G I K R M Q Y T F
Sea Urchin Strong. purpuratus XP_786803 1157 128015 S937 P G G V F D R S R M S N G G P
Poplar Tree Populus trichocarpa XP_002329539 1242 136050 D965 A S A S S N A D R R N S R S R
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FJR0 1254 136850 G970 N P N A D R R G S R G R A G G
Baker's Yeast Sacchar. cerevisiae P30771 971 109412 R813 L V I L G N P R S L A R N T L
Red Bread Mold Neurospora crassa Q9HEH1 1093 120070 D935 L T A G S V R D Y E T G S M V
Conservation
Percent
Protein Identity: 100 85.3 N.A. 98.7 N.A. 98.4 N.A. N.A. 96.6 N.A. N.A. N.A. 86 62.4 70.2 47.6 71.5
Protein Similarity: 100 85.6 N.A. 98.9 N.A. 99.1 N.A. N.A. 97.3 N.A. N.A. N.A. 89 73.7 80.5 62.6 81.3
P-Site Identity: 100 0 N.A. 93.3 N.A. 93.3 N.A. N.A. 93.3 N.A. N.A. N.A. 26.6 46.6 53.3 0 40
P-Site Similarity: 100 0 N.A. 100 N.A. 100 N.A. N.A. 100 N.A. N.A. N.A. 53.3 53.3 60 26.6 46.6
Percent
Protein Identity: 55.7 N.A. N.A. 55.2 45.4 52.7
Protein Similarity: 67.3 N.A. N.A. 67.4 61.3 67.6
P-Site Identity: 6.6 N.A. N.A. 26.6 13.3 6.6
P-Site Similarity: 26.6 N.A. N.A. 40 33.3 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 29 8 0 0 8 0 0 0 8 0 8 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 15 50 0 15 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 8 0 8 0 8 0 % E
% Phe: 8 0 0 0 8 8 0 0 0 0 0 0 0 0 8 % F
% Gly: 15 50 15 8 8 0 8 8 15 15 43 15 8 29 8 % G
% His: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 8 8 0 0 0 8 0 0 0 0 0 0 8 % I
% Lys: 0 0 0 0 0 0 0 8 8 0 0 0 0 0 0 % K
% Leu: 15 0 0 8 8 0 0 0 8 8 0 0 0 0 8 % L
% Met: 0 0 0 0 0 0 0 0 0 8 8 0 0 8 0 % M
% Asn: 8 8 8 8 0 15 0 8 0 0 8 8 15 0 29 % N
% Pro: 50 8 0 0 0 0 8 0 0 0 0 0 36 0 8 % P
% Gln: 0 0 0 0 0 0 0 0 0 29 15 8 8 0 0 % Q
% Arg: 0 0 0 0 8 15 65 8 15 22 0 50 8 0 15 % R
% Ser: 0 22 43 15 15 0 8 50 43 0 8 8 8 43 8 % S
% Thr: 0 8 0 0 0 0 8 0 8 8 8 0 0 15 8 % T
% Val: 0 8 0 43 0 8 0 0 0 0 0 8 8 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 8 43 0 0 0 8 8 8 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _