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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: UPF1 All Species: 46.36
Human Site: T325 Identified Species: 78.46
UniProt: Q92900 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q92900 NP_002902.2 1129 124345 T325 K K L K E S Q T Q D N I T V R
Chimpanzee Pan troglodytes XP_512972 974 107722 R253 P S E Q E Q L R A R Q I T A Q
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_533868 1119 123129 T326 K K L K E S Q T Q D N I T V R
Cat Felis silvestris
Mouse Mus musculus Q9EPU0 1124 123948 T320 K K L K E S Q T Q D N I T V R
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514946 1113 122992 T322 K K L K E S Q T Q D N I T V R
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres Q98TR3 1097 122320 T307 K K L K E S Q T Q D N I T V R
Fruit Fly Dros. melanogaster Q9VYS3 1180 129895 T302 Q K L K E S A T Q E N I E V R
Honey Bee Apis mellifera XP_393330 1119 125484 T309 K R L K E S Q T Q E N I E V R
Nematode Worm Caenorhab. elegans O76512 1069 120001 S297 R R V K E S A S Q A V G T V R
Sea Urchin Strong. purpuratus XP_786803 1157 128015 T314 R K L K E T Q T Q E G V T V R
Poplar Tree Populus trichocarpa XP_002329539 1242 136050 S342 K M M K E S Q S K D N V T I R
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FJR0 1254 136850 S344 K M M K E S Q S K E N L T V R
Baker's Yeast Sacchar. cerevisiae P30771 971 109412 A250 G P L I K L E A D Y D K Q L K
Red Bread Mold Neurospora crassa Q9HEH1 1093 120070 S306 K K L K E A Q S E D G L Q V R
Conservation
Percent
Protein Identity: 100 85.3 N.A. 98.7 N.A. 98.4 N.A. N.A. 96.6 N.A. N.A. N.A. 86 62.4 70.2 47.6 71.5
Protein Similarity: 100 85.6 N.A. 98.9 N.A. 99.1 N.A. N.A. 97.3 N.A. N.A. N.A. 89 73.7 80.5 62.6 81.3
P-Site Identity: 100 20 N.A. 100 N.A. 100 N.A. N.A. 100 N.A. N.A. N.A. 100 73.3 80 46.6 66.6
P-Site Similarity: 100 33.3 N.A. 100 N.A. 100 N.A. N.A. 100 N.A. N.A. N.A. 100 86.6 93.3 73.3 93.3
Percent
Protein Identity: 55.7 N.A. N.A. 55.2 45.4 52.7
Protein Similarity: 67.3 N.A. N.A. 67.4 61.3 67.6
P-Site Identity: 60 N.A. N.A. 60 6.6 60
P-Site Similarity: 93.3 N.A. N.A. 93.3 40 86.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 8 15 8 8 8 0 0 0 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 8 50 8 0 0 0 0 % D
% Glu: 0 0 8 0 93 0 8 0 8 29 0 0 15 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 8 0 0 0 0 0 0 0 0 0 15 8 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 8 0 0 0 0 0 0 0 58 0 8 0 % I
% Lys: 65 58 0 86 8 0 0 0 15 0 0 8 0 0 8 % K
% Leu: 0 0 72 0 0 8 8 0 0 0 0 15 0 8 0 % L
% Met: 0 15 15 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 65 0 0 0 0 % N
% Pro: 8 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 8 0 0 8 0 8 72 0 65 0 8 0 15 0 8 % Q
% Arg: 15 15 0 0 0 0 0 8 0 8 0 0 0 0 86 % R
% Ser: 0 8 0 0 0 72 0 29 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 8 0 58 0 0 0 0 72 0 0 % T
% Val: 0 0 8 0 0 0 0 0 0 0 8 15 0 79 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _