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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: UPF1 All Species: 17.58
Human Site: T933 Identified Species: 29.74
UniProt: Q92900 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.23
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q92900 NP_002902.2 1129 124345 T933 K P R K L V N T I N P G A R F
Chimpanzee Pan troglodytes XP_512972 974 107722 D788 L K A G A K P D Q I G I I T P
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_533868 1119 123129 T923 K P R K L V N T I N P G A R F
Cat Felis silvestris
Mouse Mus musculus Q9EPU0 1124 123948 T928 K P R K L V N T V N P G A R F
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514946 1113 122992 T919 K P R K L V N T I N P G A R F
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres Q98TR3 1097 122320 N901 S K P R K L V N T I N P R F M
Fruit Fly Dros. melanogaster Q9VYS3 1180 129895 S902 K P K K L V N S M N I G A H F
Honey Bee Apis mellifera XP_393330 1119 125484 A906 K P K K L V N A A N P G S H F
Nematode Worm Caenorhab. elegans O76512 1069 120001 A879 L Y E G P I N A L K P L N L A
Sea Urchin Strong. purpuratus XP_786803 1157 128015 P909 K P R K L I N P S N P G G R Y
Poplar Tree Populus trichocarpa XP_002329539 1242 136050 D937 K P K K I Y N D R R L F F G G
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FJR0 1254 136850 D942 K P R K I Y N D R R L F Y G G
Baker's Yeast Sacchar. cerevisiae P30771 971 109412 A785 V R A N E Q Q A I G F L R D P
Red Bread Mold Neurospora crassa Q9HEH1 1093 120070 P907 R P R Q A Y R P Q R S H T Q H
Conservation
Percent
Protein Identity: 100 85.3 N.A. 98.7 N.A. 98.4 N.A. N.A. 96.6 N.A. N.A. N.A. 86 62.4 70.2 47.6 71.5
Protein Similarity: 100 85.6 N.A. 98.9 N.A. 99.1 N.A. N.A. 97.3 N.A. N.A. N.A. 89 73.7 80.5 62.6 81.3
P-Site Identity: 100 0 N.A. 100 N.A. 93.3 N.A. N.A. 100 N.A. N.A. N.A. 0 66.6 66.6 13.3 66.6
P-Site Similarity: 100 0 N.A. 100 N.A. 100 N.A. N.A. 100 N.A. N.A. N.A. 13.3 86.6 80 26.6 80
Percent
Protein Identity: 55.7 N.A. N.A. 55.2 45.4 52.7
Protein Similarity: 67.3 N.A. N.A. 67.4 61.3 67.6
P-Site Identity: 26.6 N.A. N.A. 33.3 6.6 13.3
P-Site Similarity: 40 N.A. N.A. 40 6.6 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 15 0 15 0 0 22 8 0 0 0 36 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 22 0 0 0 0 0 8 0 % D
% Glu: 0 0 8 0 8 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 8 15 8 8 43 % F
% Gly: 0 0 0 15 0 0 0 0 0 8 8 50 8 15 15 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 8 0 15 8 % H
% Ile: 0 0 0 0 15 15 0 0 29 15 8 8 8 0 0 % I
% Lys: 65 15 22 65 8 8 0 0 0 8 0 0 0 0 0 % K
% Leu: 15 0 0 0 50 8 0 0 8 0 15 15 0 8 0 % L
% Met: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 8 % M
% Asn: 0 0 0 8 0 0 72 8 0 50 8 0 8 0 0 % N
% Pro: 0 72 8 0 8 0 8 15 0 0 50 8 0 0 15 % P
% Gln: 0 0 0 8 0 8 8 0 15 0 0 0 0 8 0 % Q
% Arg: 8 8 50 8 0 0 8 0 15 22 0 0 15 36 0 % R
% Ser: 8 0 0 0 0 0 0 8 8 0 8 0 8 0 0 % S
% Thr: 0 0 0 0 0 0 0 29 8 0 0 0 8 8 0 % T
% Val: 8 0 0 0 0 43 8 0 8 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 0 0 0 22 0 0 0 0 0 0 8 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _