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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: UPF1 All Species: 13.33
Human Site: Y1069 Identified Species: 22.56
UniProt: Q92900 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q92900 NP_002902.2 1129 124345 Y1069 Q G A L T Q G Y I S M S Q P S
Chimpanzee Pan troglodytes XP_512972 974 107722 K915 E S L M Q F S K P R K L V N T
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_533868 1119 123129 Y1059 Q G A L T Q G Y I S M S Q P S
Cat Felis silvestris
Mouse Mus musculus Q9EPU0 1124 123948 Y1064 Q G A L T Q G Y V S M S Q P S
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514946 1113 122992 Y1054 Q G P L T Q G Y I S M S Q P S
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres Q98TR3 1097 122320 H1037 G A T D T G L H L H E P A F P
Fruit Fly Dros. melanogaster Q9VYS3 1180 129895 G1094 N K K T N K L G K S R V T G G
Honey Bee Apis mellifera XP_393330 1119 125484 Q1053 P L T Q G T T Q G M S Q P G F
Nematode Worm Caenorhab. elegans O76512 1069 120001 A1007 Q Q Y P P Q G A S S Q S Q Y L
Sea Urchin Strong. purpuratus XP_786803 1157 128015 N1088 Q G V L T Q G N M S M S Q P M
Poplar Tree Populus trichocarpa XP_002329539 1242 136050 G1120 S T Q A S Q G G Y A V D Y V T
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FJR0 1254 136850 G1134 A T Q A S P G G F A V D Y A T
Baker's Yeast Sacchar. cerevisiae P30771 971 109412 E912 L S S Y I N N E Y W N F E N F
Red Bread Mold Neurospora crassa Q9HEH1 1093 120070 A1034 Q G G A S L G A G L S E A I G
Conservation
Percent
Protein Identity: 100 85.3 N.A. 98.7 N.A. 98.4 N.A. N.A. 96.6 N.A. N.A. N.A. 86 62.4 70.2 47.6 71.5
Protein Similarity: 100 85.6 N.A. 98.9 N.A. 99.1 N.A. N.A. 97.3 N.A. N.A. N.A. 89 73.7 80.5 62.6 81.3
P-Site Identity: 100 0 N.A. 100 N.A. 93.3 N.A. N.A. 93.3 N.A. N.A. N.A. 6.6 6.6 0 40 73.3
P-Site Similarity: 100 20 N.A. 100 N.A. 100 N.A. N.A. 93.3 N.A. N.A. N.A. 20 13.3 0 40 80
Percent
Protein Identity: 55.7 N.A. N.A. 55.2 45.4 52.7
Protein Similarity: 67.3 N.A. N.A. 67.4 61.3 67.6
P-Site Identity: 13.3 N.A. N.A. 6.6 0 20
P-Site Similarity: 40 N.A. N.A. 33.3 13.3 26.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 22 22 0 0 0 15 0 15 0 0 15 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 8 0 0 0 0 0 0 0 15 0 0 0 % D
% Glu: 8 0 0 0 0 0 0 8 0 0 8 8 8 0 0 % E
% Phe: 0 0 0 0 0 8 0 0 8 0 0 8 0 8 15 % F
% Gly: 8 43 8 0 8 8 65 22 15 0 0 0 0 15 15 % G
% His: 0 0 0 0 0 0 0 8 0 8 0 0 0 0 0 % H
% Ile: 0 0 0 0 8 0 0 0 22 0 0 0 0 8 0 % I
% Lys: 0 8 8 0 0 8 0 8 8 0 8 0 0 0 0 % K
% Leu: 8 8 8 36 0 8 15 0 8 8 0 8 0 0 8 % L
% Met: 0 0 0 8 0 0 0 0 8 8 36 0 0 0 8 % M
% Asn: 8 0 0 0 8 8 8 8 0 0 8 0 0 15 0 % N
% Pro: 8 0 8 8 8 8 0 0 8 0 0 8 8 36 8 % P
% Gln: 50 8 15 8 8 50 0 8 0 0 8 8 43 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 8 8 0 0 0 0 % R
% Ser: 8 15 8 0 22 0 8 0 8 50 15 43 0 0 29 % S
% Thr: 0 15 15 8 43 8 8 0 0 0 0 0 8 0 22 % T
% Val: 0 0 8 0 0 0 0 0 8 0 15 8 8 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % W
% Tyr: 0 0 8 8 0 0 0 29 15 0 0 0 15 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _