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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: UPF1 All Species: 45.76
Human Site: Y302 Identified Species: 77.44
UniProt: Q92900 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q92900 NP_002902.2 1129 124345 Y302 R Y E D A Y Q Y Q N I F G P L
Chimpanzee Pan troglodytes XP_512972 974 107722 Q230 N W D S S Q W Q P L I Q D R C
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_533868 1119 123129 Y303 R Y E D A Y Q Y Q N I F G P L
Cat Felis silvestris
Mouse Mus musculus Q9EPU0 1124 123948 Y297 R Y E D A Y Q Y Q N I F G P L
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514946 1113 122992 Y299 R Y E D A Y Q Y Q N I F G P L
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres Q98TR3 1097 122320 Y284 R Y E D A Y Q Y Q N I F G P L
Fruit Fly Dros. melanogaster Q9VYS3 1180 129895 Y279 R Y E D G Y Q Y E K T F G P L
Honey Bee Apis mellifera XP_393330 1119 125484 Y286 R Y E D G Y Q Y Q N I F G P L
Nematode Worm Caenorhab. elegans O76512 1069 120001 Y274 R Y V D A H H Y S K V F R P L
Sea Urchin Strong. purpuratus XP_786803 1157 128015 Y291 R Y E D A Y M Y Q N I F G P L
Poplar Tree Populus trichocarpa XP_002329539 1242 136050 Y319 K Y E D A Y Q Y Q N V F A P L
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FJR0 1254 136850 Y321 K Y E D A Y Q Y Q N V F A P L
Baker's Yeast Sacchar. cerevisiae P30771 971 109412 P227 E E Q E A I P P L L L R Y Q D
Red Bread Mold Neurospora crassa Q9HEH1 1093 120070 Y283 K Y D D P Y H Y Q N I F G P L
Conservation
Percent
Protein Identity: 100 85.3 N.A. 98.7 N.A. 98.4 N.A. N.A. 96.6 N.A. N.A. N.A. 86 62.4 70.2 47.6 71.5
Protein Similarity: 100 85.6 N.A. 98.9 N.A. 99.1 N.A. N.A. 97.3 N.A. N.A. N.A. 89 73.7 80.5 62.6 81.3
P-Site Identity: 100 6.6 N.A. 100 N.A. 100 N.A. N.A. 100 N.A. N.A. N.A. 100 73.3 93.3 53.3 93.3
P-Site Similarity: 100 26.6 N.A. 100 N.A. 100 N.A. N.A. 100 N.A. N.A. N.A. 100 80 93.3 66.6 93.3
Percent
Protein Identity: 55.7 N.A. N.A. 55.2 45.4 52.7
Protein Similarity: 67.3 N.A. N.A. 67.4 61.3 67.6
P-Site Identity: 80 N.A. N.A. 80 6.6 73.3
P-Site Similarity: 93.3 N.A. N.A. 93.3 26.6 86.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 72 0 0 0 0 0 0 0 15 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % C
% Asp: 0 0 15 86 0 0 0 0 0 0 0 0 8 0 8 % D
% Glu: 8 8 72 8 0 0 0 0 8 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 86 0 0 0 % F
% Gly: 0 0 0 0 15 0 0 0 0 0 0 0 65 0 0 % G
% His: 0 0 0 0 0 8 15 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 8 0 0 0 0 65 0 0 0 0 % I
% Lys: 22 0 0 0 0 0 0 0 0 15 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 8 15 8 0 0 0 86 % L
% Met: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % M
% Asn: 8 0 0 0 0 0 0 0 0 72 0 0 0 0 0 % N
% Pro: 0 0 0 0 8 0 8 8 8 0 0 0 0 86 0 % P
% Gln: 0 0 8 0 0 8 65 8 72 0 0 8 0 8 0 % Q
% Arg: 65 0 0 0 0 0 0 0 0 0 0 8 8 8 0 % R
% Ser: 0 0 0 8 8 0 0 0 8 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % T
% Val: 0 0 8 0 0 0 0 0 0 0 22 0 0 0 0 % V
% Trp: 0 8 0 0 0 0 8 0 0 0 0 0 0 0 0 % W
% Tyr: 0 86 0 0 0 79 0 86 0 0 0 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _