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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GPKOW All Species: 5.45
Human Site: S27 Identified Species: 12
UniProt: Q92917 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q92917 NP_056513.2 476 52229 S27 S F G F T R T S A R R R L A D
Chimpanzee Pan troglodytes XP_001141772 224 23867
Rhesus Macaque Macaca mulatta XP_001105674 498 55226 R46 A S W R R K L R P T W R R W C
Dog Lupus familis XP_538033 484 53417 T27 S F S F S R T T A R R R L A D
Cat Felis silvestris
Mouse Mus musculus Q56A08 488 53813 R28 F T R T S V R R R L A D L G D
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507594 502 55083 T73 V S F S F T R T A A R K R V V
Chicken Gallus gallus
Frog Xenopus laevis Q6NU07 487 54677 D27 K K K L L V S D G E K E E E H
Zebra Danio Brachydanio rerio Q90X38 506 57936 I29 G G K K A A P I S F G F S K T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623528 264 29888
Nematode Worm Caenorhab. elegans Q21924 462 51694 P32 E E N K V Q A P A K A V V I E
Sea Urchin Strong. purpuratus XP_780912 479 55253 D29 T K K G S E Q D D G E K K K R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 33.8 68.4 80.7 N.A. 74.3 N.A. N.A. 43.4 N.A. 45.7 44 N.A. N.A. 24.1 26.2 32.3
Protein Similarity: 100 38.4 73.4 88.6 N.A. 82.5 N.A. N.A. 56.3 N.A. 61.5 59.2 N.A. N.A. 39.7 47 53.4
P-Site Identity: 100 0 6.6 80 N.A. 13.3 N.A. N.A. 13.3 N.A. 0 0 N.A. N.A. 0 6.6 0
P-Site Similarity: 100 0 20 93.3 N.A. 20 N.A. N.A. 26.6 N.A. 13.3 6.6 N.A. N.A. 0 33.3 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 0 0 10 10 10 0 37 10 19 0 0 19 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % C
% Asp: 0 0 0 0 0 0 0 19 10 0 0 10 0 0 28 % D
% Glu: 10 10 0 0 0 10 0 0 0 10 10 10 10 10 10 % E
% Phe: 10 19 10 19 10 0 0 0 0 10 0 10 0 0 0 % F
% Gly: 10 10 10 10 0 0 0 0 10 10 10 0 0 10 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % H
% Ile: 0 0 0 0 0 0 0 10 0 0 0 0 0 10 0 % I
% Lys: 10 19 28 19 0 10 0 0 0 10 10 19 10 19 0 % K
% Leu: 0 0 0 10 10 0 10 0 0 10 0 0 28 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 10 10 10 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 10 10 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 10 10 10 19 19 19 10 19 28 28 19 0 10 % R
% Ser: 19 19 10 10 28 0 10 10 10 0 0 0 10 0 0 % S
% Thr: 10 10 0 10 10 10 19 19 0 10 0 0 0 0 10 % T
% Val: 10 0 0 0 10 19 0 0 0 0 0 10 10 10 10 % V
% Trp: 0 0 10 0 0 0 0 0 0 0 10 0 0 10 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _