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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: USP7 All Species: 46.06
Human Site: S253 Identified Species: 72.38
UniProt: Q93009 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q93009 NP_003461.2 1102 128302 S253 P T E G D D S S K S V P L A L
Chimpanzee Pan troglodytes XP_510806 1102 128297 S253 P T E G D D S S K S V P L A L
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_536979 1086 126326 S237 P T E G D D S S K S V P L A L
Cat Felis silvestris
Mouse Mus musculus Q6A4J8 1103 128457 S254 P T E G D D S S K S V P L A L
Rat Rattus norvegicus Q4VSI4 1103 128413 S254 P T E G D D S S K S V P L A L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506396 1145 132881 S296 P T E G D D S S K S V P L A L
Chicken Gallus gallus Q6U7I1 1101 128279 S253 P T E G D D S S K S V P L A L
Frog Xenopus laevis NP_001121282 534 61718
Zebra Danio Brachydanio rerio XP_691215 1103 128646 S254 P T E G D D S S K S V P L A L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VYQ8 1129 130428 S280 P T E A D D S S K S V G L S L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q7JKC3 1135 131579 R241 N I V L A M Q R V F Y E L Q M
Sea Urchin Strong. purpuratus XP_780569 1189 136707 S349 P T E S D D S S K S V P L A L
Poplar Tree Populus trichocarpa XP_002316470 1116 130731 S237 T T E N D I P S G S I P L A L
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q84WU2 1115 130630 T238 T T E N D A P T A S I P L A L
Baker's Yeast Sacchar. cerevisiae P50101 1230 143545 N244 P T E H E S P N N S V P L A L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.9 N.A. 97.7 N.A. 99 99 N.A. 92.4 95.9 46 94 N.A. 48.5 N.A. 34.4 54.5
Protein Similarity: 100 99.9 N.A. 98 N.A. 99.7 99.8 N.A. 94.7 97.9 47.4 96.8 N.A. 67.5 N.A. 52.5 69.2
P-Site Identity: 100 100 N.A. 100 N.A. 100 100 N.A. 100 100 0 100 N.A. 80 N.A. 6.6 93.3
P-Site Similarity: 100 100 N.A. 100 N.A. 100 100 N.A. 100 100 0 100 N.A. 86.6 N.A. 13.3 93.3
Percent
Protein Identity: 36.9 N.A. N.A. 36.5 29.4 N.A.
Protein Similarity: 54.3 N.A. N.A. 54.7 47.8 N.A.
P-Site Identity: 60 N.A. N.A. 53.3 60 N.A.
P-Site Similarity: 66.6 N.A. N.A. 66.6 73.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 7 7 7 0 0 7 0 0 0 0 80 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 80 67 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 87 0 7 0 0 0 0 0 0 7 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % F
% Gly: 0 0 0 54 0 0 0 0 7 0 0 7 0 0 0 % G
% His: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 7 0 0 0 7 0 0 0 0 14 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 67 0 0 0 0 0 0 % K
% Leu: 0 0 0 7 0 0 0 0 0 0 0 0 94 0 87 % L
% Met: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 7 % M
% Asn: 7 0 0 14 0 0 0 7 7 0 0 0 0 0 0 % N
% Pro: 74 0 0 0 0 0 20 0 0 0 0 80 0 0 0 % P
% Gln: 0 0 0 0 0 0 7 0 0 0 0 0 0 7 0 % Q
% Arg: 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 7 0 7 67 74 0 87 0 0 0 7 0 % S
% Thr: 14 87 0 0 0 0 0 7 0 0 0 0 0 0 0 % T
% Val: 0 0 7 0 0 0 0 0 7 0 74 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _