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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CUL5
All Species:
40.61
Human Site:
Y489
Identified Species:
63.81
UniProt:
Q93034
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q93034
NP_003469.2
780
90955
Y489
E
V
G
M
P
A
D
Y
V
N
K
L
A
R
M
Chimpanzee
Pan troglodytes
XP_001137909
721
84087
P463
K
N
N
K
L
A
L
P
A
D
S
V
N
I
K
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_546540
811
94684
Y520
E
V
G
M
P
A
D
Y
V
N
K
L
A
R
M
Cat
Felis silvestris
Mouse
Mus musculus
Q9D5V5
780
90956
Y489
E
V
G
M
P
A
D
Y
V
N
K
L
A
R
M
Rat
Rattus norvegicus
Q9JJ31
780
90872
Y489
E
V
G
M
P
A
D
Y
V
N
K
L
A
R
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508663
779
91022
Y488
E
V
G
M
P
A
D
Y
V
N
K
L
A
R
M
Chicken
Gallus gallus
XP_417163
809
94020
Y518
E
V
G
M
P
A
D
Y
V
N
K
L
A
R
M
Frog
Xenopus laevis
Q6GPF3
768
88937
Q492
D
E
F
R
Q
H
L
Q
T
T
G
V
S
L
G
Zebra Danio
Brachydanio rerio
XP_001922879
780
90814
Y489
E
V
G
M
P
A
D
Y
V
N
K
L
A
R
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24311
774
89493
Y499
K
Q
T
C
G
Y
E
Y
T
V
K
L
Q
R
M
Honey Bee
Apis mellifera
XP_623958
789
91733
Y502
E
V
G
M
P
A
D
Y
V
N
K
L
A
R
M
Nematode Worm
Caenorhab. elegans
Q23639
765
88890
A469
E
C
G
M
P
S
D
A
V
N
K
L
S
R
M
Sea Urchin
Strong. purpuratus
XP_787630
787
91852
Y501
E
V
G
M
P
A
D
Y
V
N
K
L
A
R
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q94AH6
738
86284
F467
K
Q
Q
C
G
G
Q
F
T
S
K
M
E
G
M
Baker's Yeast
Sacchar. cerevisiae
Q12018
815
93926
Y515
Q
A
A
N
S
M
E
Y
T
G
K
I
T
K
M
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.4
N.A.
95.8
N.A.
98.4
98.7
N.A.
98.8
95.6
27.3
95.1
N.A.
29.7
72.3
51.4
72.9
Protein Similarity:
100
92.4
N.A.
96
N.A.
99.6
99.6
N.A.
99.2
96.1
50.2
98.3
N.A.
51.2
83.4
69.3
84.5
P-Site Identity:
100
6.6
N.A.
100
N.A.
100
100
N.A.
100
100
0
100
N.A.
33.3
100
73.3
100
P-Site Similarity:
100
26.6
N.A.
100
N.A.
100
100
N.A.
100
100
20
100
N.A.
46.6
100
86.6
100
Percent
Protein Identity:
N.A.
N.A.
N.A.
24.2
23.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
48.2
44.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
7
0
0
67
0
7
7
0
0
0
60
0
0
% A
% Cys:
0
7
0
14
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
0
0
0
0
0
67
0
0
7
0
0
0
0
0
% D
% Glu:
67
7
0
0
0
0
14
0
0
0
0
0
7
0
0
% E
% Phe:
0
0
7
0
0
0
0
7
0
0
0
0
0
0
0
% F
% Gly:
0
0
67
0
14
7
0
0
0
7
7
0
0
7
7
% G
% His:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
7
0
7
0
% I
% Lys:
20
0
0
7
0
0
0
0
0
0
87
0
0
7
7
% K
% Leu:
0
0
0
0
7
0
14
0
0
0
0
74
0
7
0
% L
% Met:
0
0
0
67
0
7
0
0
0
0
0
7
0
0
87
% M
% Asn:
0
7
7
7
0
0
0
0
0
67
0
0
7
0
0
% N
% Pro:
0
0
0
0
67
0
0
7
0
0
0
0
0
0
0
% P
% Gln:
7
14
7
0
7
0
7
7
0
0
0
0
7
0
0
% Q
% Arg:
0
0
0
7
0
0
0
0
0
0
0
0
0
74
0
% R
% Ser:
0
0
0
0
7
7
0
0
0
7
7
0
14
0
0
% S
% Thr:
0
0
7
0
0
0
0
0
27
7
0
0
7
0
0
% T
% Val:
0
60
0
0
0
0
0
0
67
7
0
14
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
7
0
74
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _