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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FBXW7 All Species: 18.79
Human Site: S349 Identified Species: 31.79
UniProt: Q969H0 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.23
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q969H0 NP_001013433.1 707 79663 S349 I K P G F I H S P W K S A Y I
Chimpanzee Pan troglodytes Q5IS43 410 46712 L61 K W T S V I R L Q K K V M E L
Rhesus Macaque Macaca mulatta XP_001084190 707 79630 S349 I K P G F I H S P W K S A Y I
Dog Lupus familis XP_532689 589 66075 Q240 W K S A Y I R Q H R I D T N W
Cat Felis silvestris
Mouse Mus musculus Q8VBV4 629 70529 Q280 W K S A Y I R Q H R I D T N W
Rat Rattus norvegicus Q5BK30 415 45841 L66 R T K Q V R L L V Q R L Q E K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514172 706 79789 S348 I K P G F I H S P W K S A Y I
Chicken Gallus gallus XP_420447 702 79452 S344 I K P G F I H S P W K S A Y I
Frog Xenopus laevis Q91854 518 59489 R169 V R T D S L W R G L A E R R G
Zebra Danio Brachydanio rerio XP_693393 605 68178 Q256 W K S A Y I R Q H R I D T N W
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VZF4 1326 141343 S963 G N M P P I A S P W K A A Y M
Honey Bee Apis mellifera XP_396532 696 77358 S338 R N S G N C S S P W K Q A Y M
Nematode Worm Caenorhab. elegans Q93794 587 65293 K238 L R A D K I E K N W N A N P I
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P07834 779 86072 R350 P K L S Q Q D R L R L S F L E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 20.3 99.8 79.3 N.A. 79.4 20.6 N.A. 96.7 94 25 75.1 N.A. 37.1 59.9 37.3 N.A.
Protein Similarity: 100 33.9 100 81.1 N.A. 82.1 34.7 N.A. 98.4 96.7 42.5 78.9 N.A. 45.2 72.1 53 N.A.
P-Site Identity: 100 13.3 100 13.3 N.A. 13.3 0 N.A. 100 100 0 13.3 N.A. 46.6 46.6 20 N.A.
P-Site Similarity: 100 20 100 20 N.A. 20 6.6 N.A. 100 100 20 20 N.A. 60 53.3 40 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 24 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 42.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 22 0 0 8 0 0 0 8 15 43 0 0 % A
% Cys: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 15 0 0 8 0 0 0 0 22 0 0 0 % D
% Glu: 0 0 0 0 0 0 8 0 0 0 0 8 0 15 8 % E
% Phe: 0 0 0 0 29 0 0 0 0 0 0 0 8 0 0 % F
% Gly: 8 0 0 36 0 0 0 0 8 0 0 0 0 0 8 % G
% His: 0 0 0 0 0 0 29 0 22 0 0 0 0 0 0 % H
% Ile: 29 0 0 0 0 72 0 0 0 0 22 0 0 0 36 % I
% Lys: 8 58 8 0 8 0 0 8 0 8 50 0 0 0 8 % K
% Leu: 8 0 8 0 0 8 8 15 8 8 8 8 0 8 8 % L
% Met: 0 0 8 0 0 0 0 0 0 0 0 0 8 0 15 % M
% Asn: 0 15 0 0 8 0 0 0 8 0 8 0 8 22 0 % N
% Pro: 8 0 29 8 8 0 0 0 43 0 0 0 0 8 0 % P
% Gln: 0 0 0 8 8 8 0 22 8 8 0 8 8 0 0 % Q
% Arg: 15 15 0 0 0 8 29 15 0 29 8 0 8 8 0 % R
% Ser: 0 0 29 15 8 0 8 43 0 0 0 36 0 0 0 % S
% Thr: 0 8 15 0 0 0 0 0 0 0 0 0 22 0 0 % T
% Val: 8 0 0 0 15 0 0 0 8 0 0 8 0 0 0 % V
% Trp: 22 8 0 0 0 0 8 0 0 50 0 0 0 0 22 % W
% Tyr: 0 0 0 0 22 0 0 0 0 0 0 0 0 43 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _