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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
FBXW7
All Species:
25.15
Human Site:
S396
Identified Species:
42.56
UniProt:
Q969H0
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q969H0
NP_001013433.1
707
79663
S396
F
C
G
N
R
I
V
S
G
S
D
D
N
T
L
Chimpanzee
Pan troglodytes
Q5IS43
410
46712
R108
K
Y
A
L
S
G
H
R
S
P
V
T
R
V
I
Rhesus Macaque
Macaca mulatta
XP_001084190
707
79630
S396
F
C
G
N
R
I
V
S
G
S
D
D
N
T
L
Dog
Lupus familis
XP_532689
589
66075
V287
S
D
D
N
T
L
K
V
W
S
A
V
T
G
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8VBV4
629
70529
V327
S
D
D
N
T
L
K
V
W
S
A
V
T
G
K
Rat
Rattus norvegicus
Q5BK30
415
45841
D113
C
F
I
T
G
S
Y
D
R
T
C
K
V
W
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514172
706
79789
S395
F
C
G
N
R
I
V
S
G
S
D
D
N
T
L
Chicken
Gallus gallus
XP_420447
702
79452
S391
F
C
G
N
R
I
V
S
G
S
D
D
N
T
L
Frog
Xenopus laevis
Q91854
518
59489
R216
E
T
I
E
S
N
W
R
C
G
R
H
S
L
Q
Zebra Danio
Brachydanio rerio
XP_693393
605
68178
V303
S
D
D
N
T
L
K
V
W
S
A
V
T
G
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VZF4
1326
141343
S1010
F
S
G
N
R
I
V
S
G
S
D
D
N
T
L
Honey Bee
Apis mellifera
XP_396532
696
77358
S385
F
S
G
N
R
I
V
S
G
S
D
D
N
T
L
Nematode Worm
Caenorhab. elegans
Q93794
587
65293
K285
L
K
V
W
C
I
D
K
G
E
V
M
Y
T
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P07834
779
86072
T397
F
E
D
N
Y
V
I
T
G
A
D
D
K
M
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
20.3
99.8
79.3
N.A.
79.4
20.6
N.A.
96.7
94
25
75.1
N.A.
37.1
59.9
37.3
N.A.
Protein Similarity:
100
33.9
100
81.1
N.A.
82.1
34.7
N.A.
98.4
96.7
42.5
78.9
N.A.
45.2
72.1
53
N.A.
P-Site Identity:
100
0
100
13.3
N.A.
13.3
0
N.A.
100
100
0
13.3
N.A.
93.3
93.3
26.6
N.A.
P-Site Similarity:
100
6.6
100
20
N.A.
20
6.6
N.A.
100
100
6.6
20
N.A.
93.3
93.3
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
24
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
42.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
0
0
0
0
8
22
0
0
0
0
% A
% Cys:
8
29
0
0
8
0
0
0
8
0
8
0
0
0
0
% C
% Asp:
0
22
29
0
0
0
8
8
0
0
50
50
0
0
8
% D
% Glu:
8
8
0
8
0
0
0
0
0
8
0
0
0
0
0
% E
% Phe:
50
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
43
0
8
8
0
0
58
8
0
0
0
22
0
% G
% His:
0
0
0
0
0
0
8
0
0
0
0
8
0
0
0
% H
% Ile:
0
0
15
0
0
50
8
0
0
0
0
0
0
0
15
% I
% Lys:
8
8
0
0
0
0
22
8
0
0
0
8
8
0
22
% K
% Leu:
8
0
0
8
0
22
0
0
0
0
0
0
0
8
50
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
8
0
8
0
% M
% Asn:
0
0
0
72
0
8
0
0
0
0
0
0
43
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% Q
% Arg:
0
0
0
0
43
0
0
15
8
0
8
0
8
0
0
% R
% Ser:
22
15
0
0
15
8
0
43
8
65
0
0
8
0
0
% S
% Thr:
0
8
0
8
22
0
0
8
0
8
0
8
22
50
0
% T
% Val:
0
0
8
0
0
8
43
22
0
0
15
22
8
8
0
% V
% Trp:
0
0
0
8
0
0
8
0
22
0
0
0
0
8
0
% W
% Tyr:
0
8
0
0
8
0
8
0
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _