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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FBXW7 All Species: 26.67
Human Site: S398 Identified Species: 45.13
UniProt: Q969H0 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q969H0 NP_001013433.1 707 79663 S398 G N R I V S G S D D N T L K V
Chimpanzee Pan troglodytes Q5IS43 410 46712 P110 A L S G H R S P V T R V I F H
Rhesus Macaque Macaca mulatta XP_001084190 707 79630 S398 G N R I V S G S D D N T L K V
Dog Lupus familis XP_532689 589 66075 S289 D N T L K V W S A V T G K C L
Cat Felis silvestris
Mouse Mus musculus Q8VBV4 629 70529 S329 D N T L K V W S A V T G K C L
Rat Rattus norvegicus Q5BK30 415 45841 T115 I T G S Y D R T C K V W D T A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514172 706 79789 S397 G N R I V S G S D D N T L K V
Chicken Gallus gallus XP_420447 702 79452 S393 G N R I V S G S D D N T L K V
Frog Xenopus laevis Q91854 518 59489 G218 I E S N W R C G R H S L Q R I
Zebra Danio Brachydanio rerio XP_693393 605 68178 S305 D N T L K V W S A V T G K C L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VZF4 1326 141343 S1012 G N R I V S G S D D N T L K V
Honey Bee Apis mellifera XP_396532 696 77358 S387 G N R I V S G S D D N T L K V
Nematode Worm Caenorhab. elegans Q93794 587 65293 E287 V W C I D K G E V M Y T L V G
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P07834 779 86072 A399 D N Y V I T G A D D K M I R V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 20.3 99.8 79.3 N.A. 79.4 20.6 N.A. 96.7 94 25 75.1 N.A. 37.1 59.9 37.3 N.A.
Protein Similarity: 100 33.9 100 81.1 N.A. 82.1 34.7 N.A. 98.4 96.7 42.5 78.9 N.A. 45.2 72.1 53 N.A.
P-Site Identity: 100 0 100 13.3 N.A. 13.3 0 N.A. 100 100 0 13.3 N.A. 100 100 26.6 N.A.
P-Site Similarity: 100 6.6 100 26.6 N.A. 26.6 6.6 N.A. 100 100 20 26.6 N.A. 100 100 26.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 24 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 42.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 33.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 73.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 0 0 0 0 8 22 0 0 0 0 0 8 % A
% Cys: 0 0 8 0 0 0 8 0 8 0 0 0 0 22 0 % C
% Asp: 29 0 0 0 8 8 0 0 50 50 0 0 8 0 0 % D
% Glu: 0 8 0 0 0 0 0 8 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % F
% Gly: 43 0 8 8 0 0 58 8 0 0 0 22 0 0 8 % G
% His: 0 0 0 0 8 0 0 0 0 8 0 0 0 0 8 % H
% Ile: 15 0 0 50 8 0 0 0 0 0 0 0 15 0 8 % I
% Lys: 0 0 0 0 22 8 0 0 0 8 8 0 22 43 0 % K
% Leu: 0 8 0 22 0 0 0 0 0 0 0 8 50 0 22 % L
% Met: 0 0 0 0 0 0 0 0 0 8 0 8 0 0 0 % M
% Asn: 0 72 0 8 0 0 0 0 0 0 43 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % Q
% Arg: 0 0 43 0 0 15 8 0 8 0 8 0 0 15 0 % R
% Ser: 0 0 15 8 0 43 8 65 0 0 8 0 0 0 0 % S
% Thr: 0 8 22 0 0 8 0 8 0 8 22 50 0 8 0 % T
% Val: 8 0 0 8 43 22 0 0 15 22 8 8 0 8 50 % V
% Trp: 0 8 0 0 8 0 22 0 0 0 0 8 0 0 0 % W
% Tyr: 0 0 8 0 8 0 0 0 0 0 8 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _