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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FBXW7 All Species: 26.67
Human Site: S546 Identified Species: 45.13
UniProt: Q969H0 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q969H0 NP_001013433.1 707 79663 S546 G H T N R V Y S L Q F D G I H
Chimpanzee Pan troglodytes Q5IS43 410 46712 N254 T L I A S C S N D Q T V R V W
Rhesus Macaque Macaca mulatta XP_001084190 707 79630 S546 G H T N R V Y S L Q F D G I H
Dog Lupus familis XP_532689 589 66075 G433 V Y S L Q F D G I H V V S G S
Cat Felis silvestris
Mouse Mus musculus Q8VBV4 629 70529 G473 V Y S L Q F D G I H V V S G S
Rat Rattus norvegicus Q5BK30 415 45841 G259 R K V H T L I G H C A E I S S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514172 706 79789 S545 G H T N R V Y S L Q F D G I H
Chicken Gallus gallus XP_420447 702 79452 S541 G H T N R V Y S L Q F D G I H
Frog Xenopus laevis Q91854 518 59489 D362 R A A V N V V D F D D K Y I V
Zebra Danio Brachydanio rerio XP_693393 605 68178 G449 V Y S L Q F D G I H V V S G S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VZF4 1326 141343 S1160 G H T N R V Y S L Q F D G L H
Honey Bee Apis mellifera XP_396532 696 77358 S535 G H T N R V Y S L Q F D G V H
Nematode Worm Caenorhab. elegans Q93794 587 65293 S431 L L F E S E R S I V C S G S L
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P07834 779 86072 S575 G H T D R I Y S T I Y D H E R
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 20.3 99.8 79.3 N.A. 79.4 20.6 N.A. 96.7 94 25 75.1 N.A. 37.1 59.9 37.3 N.A.
Protein Similarity: 100 33.9 100 81.1 N.A. 82.1 34.7 N.A. 98.4 96.7 42.5 78.9 N.A. 45.2 72.1 53 N.A.
P-Site Identity: 100 6.6 100 0 N.A. 0 0 N.A. 100 100 13.3 0 N.A. 93.3 93.3 13.3 N.A.
P-Site Similarity: 100 20 100 26.6 N.A. 26.6 20 N.A. 100 100 13.3 26.6 N.A. 100 100 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 24 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 42.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 46.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 66.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 8 8 0 0 0 0 0 0 8 0 0 0 0 % A
% Cys: 0 0 0 0 0 8 0 0 0 8 8 0 0 0 0 % C
% Asp: 0 0 0 8 0 0 22 8 8 8 8 50 0 0 0 % D
% Glu: 0 0 0 8 0 8 0 0 0 0 0 8 0 8 0 % E
% Phe: 0 0 8 0 0 22 0 0 8 0 43 0 0 0 0 % F
% Gly: 50 0 0 0 0 0 0 29 0 0 0 0 50 22 0 % G
% His: 0 50 0 8 0 0 0 0 8 22 0 0 8 0 43 % H
% Ile: 0 0 8 0 0 8 8 0 29 8 0 0 8 36 0 % I
% Lys: 0 8 0 0 0 0 0 0 0 0 0 8 0 0 0 % K
% Leu: 8 15 0 22 0 8 0 0 43 0 0 0 0 8 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 43 8 0 0 8 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 22 0 0 0 0 50 0 0 0 0 0 % Q
% Arg: 15 0 0 0 50 0 8 0 0 0 0 0 8 0 8 % R
% Ser: 0 0 22 0 15 0 8 58 0 0 0 8 22 15 29 % S
% Thr: 8 0 50 0 8 0 0 0 8 0 8 0 0 0 0 % T
% Val: 22 0 8 8 0 50 8 0 0 8 22 29 0 15 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % W
% Tyr: 0 22 0 0 0 0 50 0 0 0 8 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _