Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FBXW7 All Species: 23.33
Human Site: T645 Identified Species: 39.49
UniProt: Q969H0 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.38
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q969H0 NP_001013433.1 707 79663 T645 I T S S D D G T V K L W D L K
Chimpanzee Pan troglodytes Q5IS43 410 46712 I353 F H S G G K F I L S C A D D K
Rhesus Macaque Macaca mulatta XP_001084190 707 79630 T645 I T S S D D G T V K L W D L K
Dog Lupus familis XP_532689 589 66075 D532 D G T V K L W D L K T G E F I
Cat Felis silvestris
Mouse Mus musculus Q8VBV4 629 70529 D572 D G T V K L W D L K T G E F I
Rat Rattus norvegicus Q5BK30 415 45841 N358 I S F N P Q G N R L L T G S S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514172 706 79789 T644 I T S S D D G T V K L W D L K
Chicken Gallus gallus XP_420447 702 79452 T640 I T S S D D G T V K L W D L K
Frog Xenopus laevis Q91854 518 59489 D461 D G K I K V W D L V A A L D P
Zebra Danio Brachydanio rerio XP_693393 605 68178 D548 D G T V K L W D L R T G E F I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VZF4 1326 141343 T1259 V T S S D D G T V K L W D V K
Honey Bee Apis mellifera XP_396532 696 77358 T634 I T S S D D G T V K L W D V K
Nematode Worm Caenorhab. elegans Q93794 587 65293 D530 D G T V K L W D I E R G A L I
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P07834 779 86072 S674 S Y H H T N L S A I T T F Y V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 20.3 99.8 79.3 N.A. 79.4 20.6 N.A. 96.7 94 25 75.1 N.A. 37.1 59.9 37.3 N.A.
Protein Similarity: 100 33.9 100 81.1 N.A. 82.1 34.7 N.A. 98.4 96.7 42.5 78.9 N.A. 45.2 72.1 53 N.A.
P-Site Identity: 100 20 100 6.6 N.A. 6.6 20 N.A. 100 100 0 0 N.A. 86.6 93.3 6.6 N.A.
P-Site Similarity: 100 26.6 100 26.6 N.A. 26.6 33.3 N.A. 100 100 6.6 26.6 N.A. 100 100 26.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 24 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 42.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 8 0 8 15 8 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % C
% Asp: 36 0 0 0 43 43 0 36 0 0 0 0 50 15 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 8 0 0 22 0 0 % E
% Phe: 8 0 8 0 0 0 8 0 0 0 0 0 8 22 0 % F
% Gly: 0 36 0 8 8 0 50 0 0 0 0 29 8 0 0 % G
% His: 0 8 8 8 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 43 0 0 8 0 0 0 8 8 8 0 0 0 0 29 % I
% Lys: 0 0 8 0 36 8 0 0 0 58 0 0 0 0 50 % K
% Leu: 0 0 0 0 0 29 8 0 36 8 50 0 8 36 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 8 0 8 0 8 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 8 % P
% Gln: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 8 8 8 0 0 0 0 % R
% Ser: 8 8 50 43 0 0 0 8 0 8 0 0 0 8 8 % S
% Thr: 0 43 29 0 8 0 0 43 0 0 29 15 0 0 0 % T
% Val: 8 0 0 29 0 8 0 0 43 8 0 0 0 15 8 % V
% Trp: 0 0 0 0 0 0 36 0 0 0 0 43 0 0 0 % W
% Tyr: 0 8 0 0 0 0 0 0 0 0 0 0 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _