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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TOP1MT All Species: 4.55
Human Site: S132 Identified Species: 7.14
UniProt: Q969P6 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.29
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q969P6 NP_443195.1 601 69872 S132 E E R E V I K S L D K C D F T
Chimpanzee Pan troglodytes A9Q1D5 601 69739 S132 E E R E V I K S L D K C D F T
Rhesus Macaque Macaca mulatta XP_001088021 767 90935 N298 E E K N I I T N L S K C D F T
Dog Lupus familis XP_534420 1004 115318 N535 E E K N I I T N L S K C D F T
Cat Felis silvestris
Mouse Mus musculus Q8R4U6 593 68985 H125 E E R R L I T H L D K C D F T
Rat Rattus norvegicus Q6IM78 593 68993 H125 E E R K L I T H L D K C D F S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519186 689 80888 C220 E E Q K T I K C L E E C D F T
Chicken Gallus gallus NP_001001300 593 69066 Q124 Q E Q E I I K Q L D K C D F R
Frog Xenopus laevis P41512 829 98212 N352 D E R N L I T N L S K C D F N
Zebra Danio Brachydanio rerio NP_001037789 758 89767 D289 E E K S K I T D L N K C D F S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P30189 972 111670 D519 R E R E I I K D F R K C N F Q
Honey Bee Apis mellifera XP_396203 973 114099 D522 S E R T K I V D L S K C N F K
Nematode Worm Caenorhab. elegans O17966 806 94011 D338 E E R E R I H D L K K C D F R
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P30181 916 102780 K446 G K K H V I Q K L D D C D F T
Baker's Yeast Sacchar. cerevisiae P04786 769 89977 E228 L N G I E I K E F S R C D F T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.8 53.9 43.5 N.A. 73.5 75 N.A. 67.7 73.5 48.1 54.8 N.A. 38.5 40.7 45 N.A.
Protein Similarity: 100 99.5 67.2 52.3 N.A. 83.6 84.8 N.A. 78.5 86.3 60.3 67.1 N.A. 47.9 49.5 57.4 N.A.
P-Site Identity: 100 100 60 60 N.A. 73.3 66.6 N.A. 60 66.6 53.3 53.3 N.A. 53.3 46.6 66.6 N.A.
P-Site Similarity: 100 100 80 80 N.A. 80 86.6 N.A. 86.6 86.6 73.3 73.3 N.A. 66.6 53.3 66.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 32.5 40.7 N.A.
Protein Similarity: N.A. N.A. N.A. 45.4 55.9 N.A.
P-Site Identity: N.A. N.A. N.A. 53.3 40 N.A.
P-Site Similarity: N.A. N.A. N.A. 73.3 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 7 0 0 0 100 0 0 0 % C
% Asp: 7 0 0 0 0 0 0 27 0 40 7 0 87 0 0 % D
% Glu: 60 87 0 34 7 0 0 7 0 7 7 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 14 0 0 0 0 100 0 % F
% Gly: 7 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 7 0 0 7 14 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 7 27 100 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 7 27 14 14 0 40 7 0 7 80 0 0 0 7 % K
% Leu: 7 0 0 0 20 0 0 0 87 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 7 0 20 0 0 0 20 0 7 0 0 14 0 7 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 7 0 14 0 0 0 7 7 0 0 0 0 0 0 7 % Q
% Arg: 7 0 54 7 7 0 0 0 0 7 7 0 0 0 14 % R
% Ser: 7 0 0 7 0 0 0 14 0 34 0 0 0 0 14 % S
% Thr: 0 0 0 7 7 0 40 0 0 0 0 0 0 0 54 % T
% Val: 0 0 0 0 20 0 7 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _