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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TOP1MT All Species: 37.88
Human Site: S454 Identified Species: 59.52
UniProt: Q969P6 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q969P6 NP_443195.1 601 69872 S454 S I A A K I L S Y N R A N R V
Chimpanzee Pan troglodytes A9Q1D5 601 69739 S454 S I A A K I L S Y N R A N R V
Rhesus Macaque Macaca mulatta XP_001088021 767 90935 S620 N I P A K I L S Y N R A N R A
Dog Lupus familis XP_534420 1004 115318 S857 N I P A K I L S Y N R A N R A
Cat Felis silvestris
Mouse Mus musculus Q8R4U6 593 68985 A447 S V T C K V L A Y N R A N R A
Rat Rattus norvegicus Q6IM78 593 68993 A447 S L T C K V L A Y N R A N R A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519186 689 80888 S542 N V A A K I L S Y N R A N R A
Chicken Gallus gallus NP_001001300 593 69066 S446 S V A G K L L S Y N R A N R A
Frog Xenopus laevis P41512 829 98212 S674 N V P A K I L S Y N R A N R A
Zebra Danio Brachydanio rerio NP_001037789 758 89767 S611 N V P A K I L S Y N R A N R A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P30189 972 111670 A840 T V P E K L L A Y N R A N R A
Honey Bee Apis mellifera XP_396203 973 114099 S843 T E A E K I L S Y N R A N R A
Nematode Worm Caenorhab. elegans O17966 806 94011 S667 N V A A K I L S Y N R A N R Q
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P30181 916 102780 Y764 V T Q K I V V Y Q K A N K E V
Baker's Yeast Sacchar. cerevisiae P04786 769 89977 Y545 V A E K I L K Y N A A N R T V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.8 53.9 43.5 N.A. 73.5 75 N.A. 67.7 73.5 48.1 54.8 N.A. 38.5 40.7 45 N.A.
Protein Similarity: 100 99.5 67.2 52.3 N.A. 83.6 84.8 N.A. 78.5 86.3 60.3 67.1 N.A. 47.9 49.5 57.4 N.A.
P-Site Identity: 100 100 80 80 N.A. 60 60 N.A. 80 73.3 73.3 73.3 N.A. 53.3 73.3 80 N.A.
P-Site Similarity: 100 100 86.6 86.6 N.A. 80 80 N.A. 93.3 86.6 86.6 86.6 N.A. 80 80 93.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 32.5 40.7 N.A.
Protein Similarity: N.A. N.A. N.A. 45.4 55.9 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 40 54 0 0 0 20 0 7 14 87 0 0 67 % A
% Cys: 0 0 0 14 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 7 7 14 0 0 0 0 0 0 0 0 0 7 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 27 0 0 14 60 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 14 87 0 7 0 0 7 0 0 7 0 0 % K
% Leu: 0 7 0 0 0 20 87 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 40 0 0 0 0 0 0 0 7 87 0 14 87 0 0 % N
% Pro: 0 0 34 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 7 0 0 0 0 0 7 0 0 0 0 0 7 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 87 0 7 87 0 % R
% Ser: 34 0 0 0 0 0 0 67 0 0 0 0 0 0 0 % S
% Thr: 14 7 14 0 0 0 0 0 0 0 0 0 0 7 0 % T
% Val: 14 47 0 0 0 20 7 0 0 0 0 0 0 0 27 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 14 87 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _