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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP1MT
All Species:
43.94
Human Site:
T442
Identified Species:
69.05
UniProt:
Q969P6
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q969P6
NP_443195.1
601
69872
T442
Q
E
Q
L
R
A
L
T
R
A
E
D
S
I
A
Chimpanzee
Pan troglodytes
A9Q1D5
601
69739
T442
Q
E
Q
L
R
A
L
T
R
A
E
D
S
I
A
Rhesus Macaque
Macaca mulatta
XP_001088021
767
90935
T608
Q
Q
Q
L
K
E
L
T
A
P
D
E
N
I
P
Dog
Lupus familis
XP_534420
1004
115318
T845
Q
Q
Q
L
K
E
L
T
A
P
D
E
N
I
P
Cat
Felis silvestris
Mouse
Mus musculus
Q8R4U6
593
68985
T435
Q
E
Q
L
R
V
L
T
R
A
E
D
S
V
T
Rat
Rattus norvegicus
Q6IM78
593
68993
T435
Q
E
Q
L
R
V
L
T
R
A
E
D
S
L
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519186
689
80888
T530
Q
E
Q
L
K
A
L
T
D
A
E
D
N
V
A
Chicken
Gallus gallus
NP_001001300
593
69066
T434
Q
E
Q
L
K
A
L
T
N
P
E
D
S
V
A
Frog
Xenopus laevis
P41512
829
98212
T662
Q
Q
Q
L
D
E
L
T
N
S
D
D
N
V
P
Zebra Danio
Brachydanio rerio
NP_001037789
758
89767
T599
Q
Q
Q
L
N
E
L
T
N
S
E
D
N
V
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30189
972
111670
T828
Q
S
Q
L
D
L
L
T
D
P
S
A
T
V
P
Honey Bee
Apis mellifera
XP_396203
973
114099
T831
Q
Q
Q
L
D
K
L
T
N
P
D
D
T
E
A
Nematode Worm
Caenorhab. elegans
O17966
806
94011
T655
Q
E
Q
L
I
K
L
T
N
P
K
D
N
V
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30181
916
102780
T752
D
E
M
L
S
Q
E
T
K
D
G
D
V
T
Q
Baker's Yeast
Sacchar. cerevisiae
P04786
769
89977
P533
Q
D
Q
L
D
L
I
P
N
K
G
S
V
A
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.8
53.9
43.5
N.A.
73.5
75
N.A.
67.7
73.5
48.1
54.8
N.A.
38.5
40.7
45
N.A.
Protein Similarity:
100
99.5
67.2
52.3
N.A.
83.6
84.8
N.A.
78.5
86.3
60.3
67.1
N.A.
47.9
49.5
57.4
N.A.
P-Site Identity:
100
100
40
40
N.A.
80
80
N.A.
73.3
73.3
40
46.6
N.A.
33.3
46.6
53.3
N.A.
P-Site Similarity:
100
100
73.3
73.3
N.A.
86.6
86.6
N.A.
93.3
86.6
73.3
73.3
N.A.
46.6
66.6
73.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
32.5
40.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
45.4
55.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
26.6
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
27
0
0
14
34
0
7
0
7
40
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
7
0
0
27
0
0
0
14
7
27
74
0
0
0
% D
% Glu:
0
54
0
0
0
27
7
0
0
0
47
14
0
7
7
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
14
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
7
0
7
0
0
0
0
0
0
27
0
% I
% Lys:
0
0
0
0
27
14
0
0
7
7
7
0
0
0
0
% K
% Leu:
0
0
0
100
0
14
87
0
0
0
0
0
0
7
0
% L
% Met:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
7
0
0
0
40
0
0
0
40
0
0
% N
% Pro:
0
0
0
0
0
0
0
7
0
40
0
0
0
0
34
% P
% Gln:
94
34
94
0
0
7
0
0
0
0
0
0
0
0
7
% Q
% Arg:
0
0
0
0
27
0
0
0
27
0
0
0
0
0
0
% R
% Ser:
0
7
0
0
7
0
0
0
0
14
7
7
34
0
0
% S
% Thr:
0
0
0
0
0
0
0
94
0
0
0
0
14
7
14
% T
% Val:
0
0
0
0
0
14
0
0
0
0
0
0
14
47
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _