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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HDAC10 All Species: 10.91
Human Site: S368 Identified Species: 20
UniProt: Q969S8 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q969S8 NP_001152758.1 669 71445 S368 D V T A V P M S P S S H S P E
Chimpanzee Pan troglodytes XP_515218 669 71461 S368 D V T A V P M S P S S H S P E
Rhesus Macaque Macaca mulatta XP_001112365 671 71733 S368 D V T P V P T S P S T H S P E
Dog Lupus familis XP_848669 830 88564 T368 A P T P R P G T C S A D G R T
Cat Felis silvestris
Mouse Mus musculus Q6P3E7 666 72091 S368 V A P V L S S S T H S P E E R
Rat Rattus norvegicus Q569C4 588 63939 D312 G V Y P E C S D S P D P S L D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509232 334 36373 V95 L S Q R Y D A V Y F H P E S Y
Chicken Gallus gallus
Frog Xenopus laevis NP_001089352 683 76715 P370 E I K S A H D P S S E G D S Q
Zebra Danio Brachydanio rerio NP_956069 676 74999 K370 A Q S E T N P K R P R L D A T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_727843 1138 125987 E480 Q Q T Y D C V E L Q D R D K E
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q20296 955 106730 L378 P S R T S L R L A Q W P I V N
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8LRK8 682 76616 K427 M A S N E N L K N P S A E R N
Baker's Yeast Sacchar. cerevisiae P53973 706 80051 N441 R H A N S G C N F N E P I N D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 95.2 63.8 N.A. 75.4 66.3 N.A. 33 N.A. 48.6 45.1 N.A. 26.1 N.A. 23 N.A.
Protein Similarity: 100 99.4 97.1 69.8 N.A. 83.2 72.8 N.A. 40.2 N.A. 65 61.3 N.A. 36.7 N.A. 39.2 N.A.
P-Site Identity: 100 100 80 20 N.A. 13.3 13.3 N.A. 0 N.A. 6.6 0 N.A. 13.3 N.A. 0 N.A.
P-Site Similarity: 100 100 86.6 33.3 N.A. 20 20 N.A. 0 N.A. 33.3 6.6 N.A. 20 N.A. 0 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 29.1 24.5 N.A.
Protein Similarity: N.A. N.A. N.A. 45.7 45.3 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 16 16 8 16 8 0 8 0 8 0 8 8 0 8 0 % A
% Cys: 0 0 0 0 0 16 8 0 8 0 0 0 0 0 0 % C
% Asp: 24 0 0 0 8 8 8 8 0 0 16 8 24 0 16 % D
% Glu: 8 0 0 8 16 0 0 8 0 0 16 0 24 8 31 % E
% Phe: 0 0 0 0 0 0 0 0 8 8 0 0 0 0 0 % F
% Gly: 8 0 0 0 0 8 8 0 0 0 0 8 8 0 0 % G
% His: 0 8 0 0 0 8 0 0 0 8 8 24 0 0 0 % H
% Ile: 0 8 0 0 0 0 0 0 0 0 0 0 16 0 0 % I
% Lys: 0 0 8 0 0 0 0 16 0 0 0 0 0 8 0 % K
% Leu: 8 0 0 0 8 8 8 8 8 0 0 8 0 8 0 % L
% Met: 8 0 0 0 0 0 16 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 16 0 16 0 8 8 8 0 0 0 8 16 % N
% Pro: 8 8 8 24 0 31 8 8 24 24 0 39 0 24 0 % P
% Gln: 8 16 8 0 0 0 0 0 0 16 0 0 0 0 8 % Q
% Arg: 8 0 8 8 8 0 8 0 8 0 8 8 0 16 8 % R
% Ser: 0 16 16 8 16 8 16 31 16 39 31 0 31 16 0 % S
% Thr: 0 0 39 8 8 0 8 8 8 0 8 0 0 0 16 % T
% Val: 8 31 0 8 24 0 8 8 0 0 0 0 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % W
% Tyr: 0 0 8 8 8 0 0 0 8 0 0 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _