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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMEM106A
All Species:
22.73
Human Site:
Y205
Identified Species:
55.56
UniProt:
Q96A25
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96A25
NP_659478.1
262
28920
Y205
K
I
R
D
E
N
T
Y
K
I
C
T
W
L
E
Chimpanzee
Pan troglodytes
XP_523656
262
28890
Y205
K
I
R
D
E
N
T
Y
K
I
C
T
W
L
E
Rhesus Macaque
Macaca mulatta
XP_001113491
262
28766
Y205
K
I
P
D
E
N
T
Y
K
I
C
T
W
L
E
Dog
Lupus familis
XP_548074
261
28737
Y203
K
I
K
D
E
N
T
Y
K
I
C
S
W
M
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8VC04
261
29091
Y204
R
I
L
D
E
N
T
Y
K
I
C
T
W
P
K
Rat
Rattus norvegicus
Q5BK83
261
29117
Y204
R
I
L
D
E
N
T
Y
K
I
C
T
W
P
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509431
275
30915
M208
P
T
V
I
A
D
E
M
S
Y
M
Y
D
F
C
Chicken
Gallus gallus
NP_001012576
275
30931
M208
P
T
V
I
Q
D
E
M
S
Y
M
F
D
F
C
Frog
Xenopus laevis
NP_001086334
269
29734
F206
P
T
T
I
G
N
E
F
D
Y
M
Y
S
F
C
Zebra Danio
Brachydanio rerio
NP_001038517
267
29870
Y205
T
I
A
D
E
M
S
Y
M
Y
D
Y
C
T
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
95
85.5
N.A.
66.4
67.1
N.A.
41.4
41.4
40.5
43
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.6
96.9
90.8
N.A.
80.1
81.3
N.A.
58.9
58.5
59.4
60.2
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
93.3
73.3
N.A.
73.3
73.3
N.A.
0
0
6.6
26.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
93.3
100
N.A.
86.6
86.6
N.A.
6.6
13.3
13.3
33.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
0
10
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
60
0
10
0
30
% C
% Asp:
0
0
0
70
0
20
0
0
10
0
10
0
20
0
0
% D
% Glu:
0
0
0
0
70
0
30
0
0
0
0
0
0
0
30
% E
% Phe:
0
0
0
0
0
0
0
10
0
0
0
10
0
30
0
% F
% Gly:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
70
0
30
0
0
0
0
0
60
0
0
0
0
0
% I
% Lys:
40
0
10
0
0
0
0
0
60
0
0
0
0
0
30
% K
% Leu:
0
0
20
0
0
0
0
0
0
0
0
0
0
30
10
% L
% Met:
0
0
0
0
0
10
0
20
10
0
30
0
0
10
0
% M
% Asn:
0
0
0
0
0
70
0
0
0
0
0
0
0
0
0
% N
% Pro:
30
0
10
0
0
0
0
0
0
0
0
0
0
20
0
% P
% Gln:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
20
0
20
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
10
0
20
0
0
10
10
0
0
% S
% Thr:
10
30
10
0
0
0
60
0
0
0
0
50
0
10
0
% T
% Val:
0
0
20
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
60
0
0
% W
% Tyr:
0
0
0
0
0
0
0
70
0
40
0
30
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _