KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ISL2
All Species:
34.24
Human Site:
S279
Identified Species:
68.48
UniProt:
Q96A47
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96A47
NP_665804.1
359
39768
S279
G
T
P
L
V
A
G
S
P
I
R
H
E
N
A
Chimpanzee
Pan troglodytes
Q5IS44
406
44776
T322
P
S
S
G
P
S
G
T
P
L
G
G
L
E
H
Rhesus Macaque
Macaca mulatta
XP_001105068
359
39766
S279
G
T
P
L
V
A
G
S
P
I
R
H
E
N
A
Dog
Lupus familis
XP_867861
345
38655
S265
G
T
P
M
V
A
A
S
P
E
R
H
D
G
G
Cat
Felis silvestris
Mouse
Mus musculus
Q9CXV0
359
39637
S279
G
T
P
L
V
A
G
S
P
I
G
H
E
N
A
Rat
Rattus norvegicus
P50480
360
39657
S280
G
T
L
L
V
A
G
S
P
S
A
H
E
N
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508080
665
71117
S585
G
T
P
M
V
A
A
S
P
E
R
H
D
G
G
Chicken
Gallus gallus
P50211
349
39015
S269
G
T
P
M
V
A
A
S
P
E
R
H
D
G
G
Frog
Xenopus laevis
P29674
403
44916
T321
P
S
S
V
P
A
G
T
P
L
G
A
M
D
H
Zebra Danio
Brachydanio rerio
P53406
359
40208
S279
G
T
P
L
V
A
G
S
P
I
R
H
D
T
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_476775
534
58026
S330
G
I
P
M
I
A
S
S
P
V
R
H
D
S
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781774
401
45310
V304
P
M
V
A
S
S
P
V
R
H
D
S
Q
M
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
30.5
99.7
73.8
N.A.
97.4
96.3
N.A.
40.9
74
29.5
88
N.A.
42.7
N.A.
N.A.
56.8
Protein Similarity:
100
45.5
100
83.5
N.A.
98.3
97.2
N.A.
47
83.8
46.9
92.7
N.A.
50.3
N.A.
N.A.
67.8
P-Site Identity:
100
13.3
100
60
N.A.
93.3
80
N.A.
60
60
20
80
N.A.
46.6
N.A.
N.A.
0
P-Site Similarity:
100
40
100
73.3
N.A.
93.3
80
N.A.
73.3
73.3
53.3
86.6
N.A.
80
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
9
0
84
25
0
0
0
9
9
0
0
34
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
9
0
42
9
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
25
0
0
34
9
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
75
0
0
9
0
0
59
0
0
0
25
9
0
25
25
% G
% His:
0
0
0
0
0
0
0
0
0
9
0
75
0
0
17
% H
% Ile:
0
9
0
0
9
0
0
0
0
34
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
9
42
0
0
0
0
0
17
0
0
9
0
0
% L
% Met:
0
9
0
34
0
0
0
0
0
0
0
0
9
9
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
34
0
% N
% Pro:
25
0
67
0
17
0
9
0
92
0
0
0
0
0
17
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
9
0
59
0
0
0
0
% R
% Ser:
0
17
17
0
9
17
9
75
0
9
0
9
0
9
0
% S
% Thr:
0
67
0
0
0
0
0
17
0
0
0
0
0
9
9
% T
% Val:
0
0
9
9
67
0
0
9
0
9
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _