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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ISOC2
All Species:
30
Human Site:
S103
Identified Species:
60
UniProt:
Q96AB3
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96AB3
NP_001129673.1
205
22337
S103
D
S
R
P
Q
L
R
S
V
L
L
C
G
I
E
Chimpanzee
Pan troglodytes
XP_001135720
220
24001
S103
D
S
R
P
Q
L
R
S
V
L
L
C
G
I
E
Rhesus Macaque
Macaca mulatta
XP_001088057
205
22323
S103
D
S
R
P
Q
L
R
S
V
L
L
C
G
I
E
Dog
Lupus familis
XP_850761
204
22220
S102
E
S
R
P
Q
L
C
S
V
L
L
C
G
I
E
Cat
Felis silvestris
Mouse
Mus musculus
P85094
206
22399
S103
D
G
R
S
Q
L
Q
S
V
L
L
C
G
I
E
Rat
Rattus norvegicus
Q5U3Z3
210
23139
S103
D
K
L
P
Q
L
K
S
V
L
L
C
G
I
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521429
466
49169
R248
L
E
A
R
P
G
L
R
S
V
L
L
C
G
I
Chicken
Gallus gallus
XP_413969
292
31709
S198
A
E
I
P
G
V
R
S
V
V
L
F
G
V
E
Frog
Xenopus laevis
Q5PQ71
205
22642
R102
L
Q
S
I
P
D
L
R
S
I
V
L
C
G
I
Zebra Danio
Brachydanio rerio
Q08C33
283
31307
S189
A
E
I
P
G
V
R
S
V
V
L
F
G
V
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_502315
199
21831
N103
D
T
L
K
K
V
Q
N
V
I
L
V
G
I
E
Sea Urchin
Strong. purpuratus
XP_795064
195
21855
T103
L
K
E
N
D
T
K
T
V
V
L
C
G
I
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
82.2
95.6
88.7
N.A.
83
73.3
N.A.
30.8
38.3
66.3
37.4
N.A.
N.A.
N.A.
51.7
54.1
Protein Similarity:
100
86.8
97.5
93.6
N.A.
91.2
83.3
N.A.
36.4
49.6
83.4
50.5
N.A.
N.A.
N.A.
68.2
73.6
P-Site Identity:
100
100
100
86.6
N.A.
80
80
N.A.
6.6
46.6
0
46.6
N.A.
N.A.
N.A.
40
40
P-Site Similarity:
100
100
100
93.3
N.A.
86.6
86.6
N.A.
13.3
66.6
13.3
66.6
N.A.
N.A.
N.A.
80
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
17
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
9
0
0
0
0
59
17
0
0
% C
% Asp:
50
0
0
0
9
9
0
0
0
0
0
0
0
0
0
% D
% Glu:
9
25
9
0
0
0
0
0
0
0
0
0
0
0
84
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
17
0
0
0
% F
% Gly:
0
9
0
0
17
9
0
0
0
0
0
0
84
17
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
17
9
0
0
0
0
0
17
0
0
0
67
17
% I
% Lys:
0
17
0
9
9
0
17
0
0
0
0
0
0
0
0
% K
% Leu:
25
0
17
0
0
50
17
0
0
50
92
17
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
9
0
0
0
9
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
59
17
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
9
0
0
50
0
17
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
42
9
0
0
42
17
0
0
0
0
0
0
0
% R
% Ser:
0
34
9
9
0
0
0
67
17
0
0
0
0
0
0
% S
% Thr:
0
9
0
0
0
9
0
9
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
25
0
0
84
34
9
9
0
17
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _