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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ISOC2 All Species: 8.48
Human Site: S202 Identified Species: 16.97
UniProt: Q96AB3 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96AB3 NP_001129673.1 205 22337 S202 G L F Q G Q N S L L H _ _ _ _
Chimpanzee Pan troglodytes XP_001135720 220 24001 S217 G L F Q G Q N S L L H _ _ _ _
Rhesus Macaque Macaca mulatta XP_001088057 205 22323 P202 G L F Q G Q N P L L H _ _ _ _
Dog Lupus familis XP_850761 204 22220 P201 G L F Q G Q N P L F R _ _ _ _
Cat Felis silvestris
Mouse Mus musculus P85094 206 22399 P202 S L F Q G Q S P L T S C _ _ _
Rat Rattus norvegicus Q5U3Z3 210 23139 N202 G F F Q G M N N P L L P N S R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521429 466 49169 S422 Q L P W Q R D S I L L W E H G
Chicken Gallus gallus XP_413969 292 31709 G287 K A S A P E S G L L S K V _ _
Frog Xenopus laevis Q5PQ71 205 22642 L202 S L F R G P N L F S T _ _ _ _
Zebra Danio Brachydanio rerio Q08C33 283 31307 G278 K V S A P E S G L L S K V _ _
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans NP_502315 199 21831 T191 I L T S A P D T G L V P L S K
Sea Urchin Strong. purpuratus XP_795064 195 21855 S187 I Q K V I A T S A P D S G L L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 82.2 95.6 88.7 N.A. 83 73.3 N.A. 30.8 38.3 66.3 37.4 N.A. N.A. N.A. 51.7 54.1
Protein Similarity: 100 86.8 97.5 93.6 N.A. 91.2 83.3 N.A. 36.4 49.6 83.4 50.5 N.A. N.A. N.A. 68.2 73.6
P-Site Identity: 100 100 90.9 72.7 N.A. 50 40 N.A. 20 15.3 36.3 15.3 N.A. N.A. N.A. 13.3 6.6
P-Site Similarity: 100 100 90.9 72.7 N.A. 58.3 46.6 N.A. 46.6 30.7 45.4 38.4 N.A. N.A. N.A. 26.6 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 9 0 17 9 9 0 0 9 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % C
% Asp: 0 0 0 0 0 0 17 0 0 0 9 0 0 0 0 % D
% Glu: 0 0 0 0 0 17 0 0 0 0 0 0 9 0 0 % E
% Phe: 0 9 59 0 0 0 0 0 9 9 0 0 0 0 0 % F
% Gly: 42 0 0 0 59 0 0 17 9 0 0 0 9 0 9 % G
% His: 0 0 0 0 0 0 0 0 0 0 25 0 0 9 0 % H
% Ile: 17 0 0 0 9 0 0 0 9 0 0 0 0 0 0 % I
% Lys: 17 0 9 0 0 0 0 0 0 0 0 17 0 0 9 % K
% Leu: 0 67 0 0 0 0 0 9 59 67 17 0 9 9 9 % L
% Met: 0 0 0 0 0 9 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 50 9 0 0 0 0 9 0 0 % N
% Pro: 0 0 9 0 17 17 0 25 9 9 0 17 0 0 0 % P
% Gln: 9 9 0 50 9 42 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 9 0 9 0 0 0 0 9 0 0 0 9 % R
% Ser: 17 0 17 9 0 0 25 34 0 9 25 9 0 17 0 % S
% Thr: 0 0 9 0 0 0 9 9 0 9 9 0 0 0 0 % T
% Val: 0 9 0 9 0 0 0 0 0 0 9 0 17 0 0 % V
% Trp: 0 0 0 9 0 0 0 0 0 0 0 9 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 42 50 67 67 % _