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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PNPLA2
All Species:
26.36
Human Site:
S199
Identified Species:
48.33
UniProt:
Q96AD5
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96AD5
NP_065109.1
504
55316
S199
D
I
C
P
Q
D
S
S
T
N
I
H
E
L
R
Chimpanzee
Pan troglodytes
XP_525619
429
47940
C196
F
H
G
T
V
D
I
C
P
Q
S
T
S
P
N
Rhesus Macaque
Macaca mulatta
XP_001109144
481
53057
S199
D
I
C
P
K
V
K
S
T
N
F
L
H
V
D
Dog
Lupus familis
XP_854164
454
49903
S199
D
I
C
P
Q
D
S
S
T
N
I
H
E
L
R
Cat
Felis silvestris
Mouse
Mus musculus
Q8BJ56
486
53638
S199
D
I
C
P
Q
D
S
S
T
N
I
H
E
L
R
Rat
Rattus norvegicus
P0C548
478
52548
S199
D
I
C
P
Q
D
S
S
T
N
I
H
E
L
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509841
390
42660
I155
V
P
I
Y
C
G
L
I
P
P
S
F
Q
G
E
Chicken
Gallus gallus
NP_001106762
483
53464
S199
D
I
C
P
R
D
S
S
T
N
M
R
E
L
R
Frog
Xenopus laevis
NP_001087449
506
56166
N199
D
I
C
P
R
D
T
N
S
T
N
F
H
E
V
Zebra Danio
Brachydanio rerio
NP_001002338
473
52215
S199
D
I
C
P
K
D
N
S
T
S
F
H
E
L
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001163445
553
62224
V253
N
C
R
R
C
V
A
V
Q
S
T
F
V
V
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q11186
621
69345
S200
I
C
P
P
D
W
D
S
G
S
M
L
G
V
D
Sea Urchin
Strong. purpuratus
XP_787685
643
72506
R268
S
V
C
L
G
N
T
R
M
S
S
R
P
S
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
33.1
34.7
82.1
N.A.
84.3
84.1
N.A.
36.1
65.8
50
48.2
N.A.
32.7
N.A.
30.2
30.4
Protein Similarity:
100
46.8
51.5
84.5
N.A.
88.2
87.9
N.A.
50.2
75.7
65
62.9
N.A.
49
N.A.
47.5
46.3
P-Site Identity:
100
6.6
46.6
100
N.A.
100
100
N.A.
0
80
33.3
73.3
N.A.
0
N.A.
13.3
6.6
P-Site Similarity:
100
6.6
60
100
N.A.
100
100
N.A.
6.6
93.3
60
93.3
N.A.
26.6
N.A.
33.3
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% A
% Cys:
0
16
70
0
16
0
0
8
0
0
0
0
0
0
0
% C
% Asp:
62
0
0
0
8
62
8
0
0
0
0
0
0
0
16
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
47
8
8
% E
% Phe:
8
0
0
0
0
0
0
0
0
0
16
24
0
0
0
% F
% Gly:
0
0
8
0
8
8
0
0
8
0
0
0
8
8
0
% G
% His:
0
8
0
0
0
0
0
0
0
0
0
39
16
0
0
% H
% Ile:
8
62
8
0
0
0
8
8
0
0
31
0
0
0
0
% I
% Lys:
0
0
0
0
16
0
8
0
0
0
0
0
0
0
8
% K
% Leu:
0
0
0
8
0
0
8
0
0
0
0
16
0
47
0
% L
% Met:
0
0
0
0
0
0
0
0
8
0
16
0
0
0
0
% M
% Asn:
8
0
0
0
0
8
8
8
0
47
8
0
0
0
8
% N
% Pro:
0
8
8
70
0
0
0
0
16
8
0
0
8
8
0
% P
% Gln:
0
0
0
0
31
0
0
0
8
8
0
0
8
0
0
% Q
% Arg:
0
0
8
8
16
0
0
8
0
0
0
16
0
0
47
% R
% Ser:
8
0
0
0
0
0
39
62
8
31
24
0
8
8
8
% S
% Thr:
0
0
0
8
0
0
16
0
54
8
8
8
0
0
0
% T
% Val:
8
8
0
0
8
16
0
8
0
0
0
0
8
24
8
% V
% Trp:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _