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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PNPLA2 All Species: 14.85
Human Site: S407 Identified Species: 27.22
UniProt: Q96AD5 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96AD5 NP_065109.1 504 55316 S407 R R V Q S L P S V P L S C A A
Chimpanzee Pan troglodytes XP_525619 429 47940 F357 L P F E Y I Y F R S R R L V V
Rhesus Macaque Macaca mulatta XP_001109144 481 53057 T390 V Q W L Q W V T S Q V F T R A
Dog Lupus familis XP_854164 454 49903 S380 R R T Q S L P S V P L S C A A
Cat Felis silvestris
Mouse Mus musculus Q8BJ56 486 53638 S409 R R A Q S L P S V P L S C A T
Rat Rattus norvegicus P0C548 478 52548 S401 R R A Q S L P S V P L S C A T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509841 390 42660 L316 L G I L S P A L S K A L N A A
Chicken Gallus gallus NP_001106762 483 53464 I411 G G P Q S L P I S S A S P C G
Frog Xenopus laevis NP_001087449 506 56166 L423 C L S L P P P L H H A T S Y L
Zebra Danio Brachydanio rerio NP_001002338 473 52215 E371 R F W E W I P E V P A D V R W
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001163445 553 62224 T460 T E H D K L A T D L Q I Y E G
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q11186 621 69345 E496 N S E N Q F D E T S V Y D V D
Sea Urchin Strong. purpuratus XP_787685 643 72506 T547 L P D C V M D T F D F S E D L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 33.1 34.7 82.1 N.A. 84.3 84.1 N.A. 36.1 65.8 50 48.2 N.A. 32.7 N.A. 30.2 30.4
Protein Similarity: 100 46.8 51.5 84.5 N.A. 88.2 87.9 N.A. 50.2 75.7 65 62.9 N.A. 49 N.A. 47.5 46.3
P-Site Identity: 100 0 6.6 93.3 N.A. 86.6 86.6 N.A. 20 33.3 6.6 26.6 N.A. 6.6 N.A. 0 6.6
P-Site Similarity: 100 13.3 26.6 93.3 N.A. 86.6 86.6 N.A. 26.6 33.3 13.3 40 N.A. 13.3 N.A. 6.6 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 16 0 0 0 16 0 0 0 31 0 0 39 31 % A
% Cys: 8 0 0 8 0 0 0 0 0 0 0 0 31 8 0 % C
% Asp: 0 0 8 8 0 0 16 0 8 8 0 8 8 8 8 % D
% Glu: 0 8 8 16 0 0 0 16 0 0 0 0 8 8 0 % E
% Phe: 0 8 8 0 0 8 0 8 8 0 8 8 0 0 0 % F
% Gly: 8 16 0 0 0 0 0 0 0 0 0 0 0 0 16 % G
% His: 0 0 8 0 0 0 0 0 8 8 0 0 0 0 0 % H
% Ile: 0 0 8 0 0 16 0 8 0 0 0 8 0 0 0 % I
% Lys: 0 0 0 0 8 0 0 0 0 8 0 0 0 0 0 % K
% Leu: 24 8 0 24 0 47 0 16 0 8 31 8 8 0 16 % L
% Met: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % M
% Asn: 8 0 0 8 0 0 0 0 0 0 0 0 8 0 0 % N
% Pro: 0 16 8 0 8 16 54 0 0 39 0 0 8 0 0 % P
% Gln: 0 8 0 39 16 0 0 0 0 8 8 0 0 0 0 % Q
% Arg: 39 31 0 0 0 0 0 0 8 0 8 8 0 16 0 % R
% Ser: 0 8 8 0 47 0 0 31 24 24 0 47 8 0 0 % S
% Thr: 8 0 8 0 0 0 0 24 8 0 0 8 8 0 16 % T
% Val: 8 0 8 0 8 0 8 0 39 0 16 0 8 16 8 % V
% Trp: 0 0 16 0 8 8 0 0 0 0 0 0 0 0 8 % W
% Tyr: 0 0 0 0 8 0 8 0 0 0 0 8 8 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _