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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PNPLA2
All Species:
14.85
Human Site:
S407
Identified Species:
27.22
UniProt:
Q96AD5
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96AD5
NP_065109.1
504
55316
S407
R
R
V
Q
S
L
P
S
V
P
L
S
C
A
A
Chimpanzee
Pan troglodytes
XP_525619
429
47940
F357
L
P
F
E
Y
I
Y
F
R
S
R
R
L
V
V
Rhesus Macaque
Macaca mulatta
XP_001109144
481
53057
T390
V
Q
W
L
Q
W
V
T
S
Q
V
F
T
R
A
Dog
Lupus familis
XP_854164
454
49903
S380
R
R
T
Q
S
L
P
S
V
P
L
S
C
A
A
Cat
Felis silvestris
Mouse
Mus musculus
Q8BJ56
486
53638
S409
R
R
A
Q
S
L
P
S
V
P
L
S
C
A
T
Rat
Rattus norvegicus
P0C548
478
52548
S401
R
R
A
Q
S
L
P
S
V
P
L
S
C
A
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509841
390
42660
L316
L
G
I
L
S
P
A
L
S
K
A
L
N
A
A
Chicken
Gallus gallus
NP_001106762
483
53464
I411
G
G
P
Q
S
L
P
I
S
S
A
S
P
C
G
Frog
Xenopus laevis
NP_001087449
506
56166
L423
C
L
S
L
P
P
P
L
H
H
A
T
S
Y
L
Zebra Danio
Brachydanio rerio
NP_001002338
473
52215
E371
R
F
W
E
W
I
P
E
V
P
A
D
V
R
W
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001163445
553
62224
T460
T
E
H
D
K
L
A
T
D
L
Q
I
Y
E
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q11186
621
69345
E496
N
S
E
N
Q
F
D
E
T
S
V
Y
D
V
D
Sea Urchin
Strong. purpuratus
XP_787685
643
72506
T547
L
P
D
C
V
M
D
T
F
D
F
S
E
D
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
33.1
34.7
82.1
N.A.
84.3
84.1
N.A.
36.1
65.8
50
48.2
N.A.
32.7
N.A.
30.2
30.4
Protein Similarity:
100
46.8
51.5
84.5
N.A.
88.2
87.9
N.A.
50.2
75.7
65
62.9
N.A.
49
N.A.
47.5
46.3
P-Site Identity:
100
0
6.6
93.3
N.A.
86.6
86.6
N.A.
20
33.3
6.6
26.6
N.A.
6.6
N.A.
0
6.6
P-Site Similarity:
100
13.3
26.6
93.3
N.A.
86.6
86.6
N.A.
26.6
33.3
13.3
40
N.A.
13.3
N.A.
6.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
16
0
0
0
16
0
0
0
31
0
0
39
31
% A
% Cys:
8
0
0
8
0
0
0
0
0
0
0
0
31
8
0
% C
% Asp:
0
0
8
8
0
0
16
0
8
8
0
8
8
8
8
% D
% Glu:
0
8
8
16
0
0
0
16
0
0
0
0
8
8
0
% E
% Phe:
0
8
8
0
0
8
0
8
8
0
8
8
0
0
0
% F
% Gly:
8
16
0
0
0
0
0
0
0
0
0
0
0
0
16
% G
% His:
0
0
8
0
0
0
0
0
8
8
0
0
0
0
0
% H
% Ile:
0
0
8
0
0
16
0
8
0
0
0
8
0
0
0
% I
% Lys:
0
0
0
0
8
0
0
0
0
8
0
0
0
0
0
% K
% Leu:
24
8
0
24
0
47
0
16
0
8
31
8
8
0
16
% L
% Met:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
0
8
0
0
0
0
0
0
0
0
8
0
0
% N
% Pro:
0
16
8
0
8
16
54
0
0
39
0
0
8
0
0
% P
% Gln:
0
8
0
39
16
0
0
0
0
8
8
0
0
0
0
% Q
% Arg:
39
31
0
0
0
0
0
0
8
0
8
8
0
16
0
% R
% Ser:
0
8
8
0
47
0
0
31
24
24
0
47
8
0
0
% S
% Thr:
8
0
8
0
0
0
0
24
8
0
0
8
8
0
16
% T
% Val:
8
0
8
0
8
0
8
0
39
0
16
0
8
16
8
% V
% Trp:
0
0
16
0
8
8
0
0
0
0
0
0
0
0
8
% W
% Tyr:
0
0
0
0
8
0
8
0
0
0
0
8
8
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _