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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PNPLA2
All Species:
7.58
Human Site:
S489
Identified Species:
13.89
UniProt:
Q96AD5
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96AD5
NP_065109.1
504
55316
S489
A
G
P
A
P
L
L
S
T
P
A
P
E
A
R
Chimpanzee
Pan troglodytes
XP_525619
429
47940
E421
P
Q
I
A
P
H
R
E
E
L
G
P
T
H
Q
Rhesus Macaque
Macaca mulatta
XP_001109144
481
53057
S470
P
A
G
A
E
G
L
S
T
F
P
S
F
S
L
Dog
Lupus familis
XP_854164
454
49903
S445
A
G
P
A
P
R
P
S
Q
L
P
P
S
S
P
Cat
Felis silvestris
Mouse
Mus musculus
Q8BJ56
486
53638
A475
S
P
T
A
A
D
P
A
T
P
Q
D
P
P
G
Rat
Rattus norvegicus
P0C548
478
52548
A467
S
P
T
A
T
D
P
A
T
P
Q
D
P
S
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509841
390
42660
Q380
D
D
I
C
W
L
L
Q
H
I
V
G
V
V
R
Chicken
Gallus gallus
NP_001106762
483
53464
C475
M
K
L
P
P
L
D
C
A
K
E
C
L
P
L
Frog
Xenopus laevis
NP_001087449
506
56166
S489
S
G
V
D
V
N
F
S
T
D
P
E
D
S
A
Zebra Danio
Brachydanio rerio
NP_001002338
473
52215
C453
H
T
T
S
S
I
D
C
P
E
S
P
V
S
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001163445
553
62224
S528
E
S
D
A
S
V
L
S
D
P
E
V
D
Q
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q11186
621
69345
E594
H
G
G
Q
E
I
V
E
L
G
E
S
D
K
D
Sea Urchin
Strong. purpuratus
XP_787685
643
72506
H461
S
G
L
T
N
I
L
H
L
I
A
S
N
M
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
33.1
34.7
82.1
N.A.
84.3
84.1
N.A.
36.1
65.8
50
48.2
N.A.
32.7
N.A.
30.2
30.4
Protein Similarity:
100
46.8
51.5
84.5
N.A.
88.2
87.9
N.A.
50.2
75.7
65
62.9
N.A.
49
N.A.
47.5
46.3
P-Site Identity:
100
20
26.6
46.6
N.A.
20
20
N.A.
20
13.3
20
6.6
N.A.
26.6
N.A.
6.6
20
P-Site Similarity:
100
26.6
33.3
53.3
N.A.
33.3
40
N.A.
20
13.3
40
33.3
N.A.
40
N.A.
26.6
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
8
0
54
8
0
0
16
8
0
16
0
0
8
8
% A
% Cys:
0
0
0
8
0
0
0
16
0
0
0
8
0
0
0
% C
% Asp:
8
8
8
8
0
16
16
0
8
8
0
16
24
0
8
% D
% Glu:
8
0
0
0
16
0
0
16
8
8
24
8
8
0
8
% E
% Phe:
0
0
0
0
0
0
8
0
0
8
0
0
8
0
0
% F
% Gly:
0
39
16
0
0
8
0
0
0
8
8
8
0
0
24
% G
% His:
16
0
0
0
0
8
0
8
8
0
0
0
0
8
0
% H
% Ile:
0
0
16
0
0
24
0
0
0
16
0
0
0
0
0
% I
% Lys:
0
8
0
0
0
0
0
0
0
8
0
0
0
8
0
% K
% Leu:
0
0
16
0
0
24
39
0
16
16
0
0
8
0
16
% L
% Met:
8
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
0
0
0
0
8
8
0
0
0
0
0
0
8
0
0
% N
% Pro:
16
16
16
8
31
0
24
0
8
31
24
31
16
16
8
% P
% Gln:
0
8
0
8
0
0
0
8
8
0
16
0
0
8
8
% Q
% Arg:
0
0
0
0
0
8
8
0
0
0
0
0
0
0
16
% R
% Ser:
31
8
0
8
16
0
0
39
0
0
8
24
8
39
0
% S
% Thr:
0
8
24
8
8
0
0
0
39
0
0
0
8
0
8
% T
% Val:
0
0
8
0
8
8
8
0
0
0
8
8
16
8
0
% V
% Trp:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _