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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EXOSC8 All Species: 35.15
Human Site: T257 Identified Species: 77.33
UniProt: Q96B26 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96B26 NP_852480.1 276 30040 T257 D C M S R A V T R H K E V K K
Chimpanzee Pan troglodytes XP_522661 276 30031 T257 D C M S R A V T R H K E V K K
Rhesus Macaque Macaca mulatta XP_001085228 276 30003 T257 D C M S R A V T R H K E V K K
Dog Lupus familis XP_534492 276 29977 T257 D C M S R A V T R H K E V K K
Cat Felis silvestris
Mouse Mus musculus Q9D753 276 29931 T257 D C M S R A V T R H K E V S K
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511768 276 29817 T257 D C L S R A V T R H K E V K V
Chicken Gallus gallus
Frog Xenopus laevis NP_001088781 276 29933 T257 E C I S R A I T R H K E V T T
Zebra Danio Brachydanio rerio NP_001002865 277 30364 T257 H C I N R A L T R N K E I R K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_624000 281 30977 K256 K S L I K S K K R A E L V R S
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_796992 275 29794 T257 D C I G R A Q T R A K E I C S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q05636 305 33943 S270 K C C H E A Y S I I E K I T D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 99.2 97.4 N.A. 92 N.A. N.A. 88 N.A. 75.3 70.4 N.A. N.A. 45.2 N.A. 59.7
Protein Similarity: 100 99.6 99.2 98.5 N.A. 97 N.A. N.A. 93.1 N.A. 84.7 84.8 N.A. N.A. 67.2 N.A. 80
P-Site Identity: 100 100 100 100 N.A. 93.3 N.A. N.A. 86.6 N.A. 66.6 53.3 N.A. N.A. 13.3 N.A. 53.3
P-Site Similarity: 100 100 100 100 N.A. 93.3 N.A. N.A. 93.3 N.A. 86.6 93.3 N.A. N.A. 46.6 N.A. 66.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 26.8 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 47.2 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 91 0 0 0 19 0 0 0 0 0 % A
% Cys: 0 91 10 0 0 0 0 0 0 0 0 0 0 10 0 % C
% Asp: 64 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % D
% Glu: 10 0 0 0 10 0 0 0 0 0 19 82 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 10 0 0 10 0 0 0 0 0 64 0 0 0 0 0 % H
% Ile: 0 0 28 10 0 0 10 0 10 10 0 0 28 0 0 % I
% Lys: 19 0 0 0 10 0 10 10 0 0 82 10 0 46 55 % K
% Leu: 0 0 19 0 0 0 10 0 0 0 0 10 0 0 0 % L
% Met: 0 0 46 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 10 0 0 0 0 0 10 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 82 0 0 0 91 0 0 0 0 19 0 % R
% Ser: 0 10 0 64 0 10 0 10 0 0 0 0 0 10 19 % S
% Thr: 0 0 0 0 0 0 0 82 0 0 0 0 0 19 10 % T
% Val: 0 0 0 0 0 0 55 0 0 0 0 0 73 0 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _