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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EXOSC8
All Species:
20
Human Site:
Y186
Identified Species:
44
UniProt:
Q96B26
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96B26
NP_852480.1
276
30040
Y186
V
N
L
K
K
K
S
Y
L
N
I
R
T
H
P
Chimpanzee
Pan troglodytes
XP_522661
276
30031
Y186
V
N
L
K
K
K
S
Y
L
N
I
R
T
H
P
Rhesus Macaque
Macaca mulatta
XP_001085228
276
30003
Y186
V
N
L
K
K
K
S
Y
L
N
I
R
T
H
P
Dog
Lupus familis
XP_534492
276
29977
Y186
V
N
L
K
K
K
S
Y
L
N
I
R
T
H
P
Cat
Felis silvestris
Mouse
Mus musculus
Q9D753
276
29931
Y186
V
N
L
K
K
K
S
Y
L
N
V
R
T
N
P
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511768
276
29817
P186
V
N
F
K
Q
K
T
P
L
N
I
R
A
Y
P
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001088781
276
29933
A186
V
N
L
K
T
K
C
A
L
K
I
L
K
H
P
Zebra Danio
Brachydanio rerio
NP_001002865
277
30364
R186
V
D
I
E
K
K
R
R
L
K
I
N
R
H
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_624000
281
30977
R186
I
N
S
T
K
R
I
R
F
P
I
K
A
L
P
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796992
275
29794
S186
L
S
S
T
E
D
R
S
L
N
I
V
N
Q
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q05636
305
33943
P186
V
N
E
R
E
P
V
P
L
G
I
L
H
I
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
99.2
97.4
N.A.
92
N.A.
N.A.
88
N.A.
75.3
70.4
N.A.
N.A.
45.2
N.A.
59.7
Protein Similarity:
100
99.6
99.2
98.5
N.A.
97
N.A.
N.A.
93.1
N.A.
84.7
84.8
N.A.
N.A.
67.2
N.A.
80
P-Site Identity:
100
100
100
100
N.A.
86.6
N.A.
N.A.
60
N.A.
60
46.6
N.A.
N.A.
26.6
N.A.
20
P-Site Similarity:
100
100
100
100
N.A.
100
N.A.
N.A.
80
N.A.
60
66.6
N.A.
N.A.
46.6
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
26.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
47.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
10
0
0
0
0
19
0
0
% A
% Cys:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
0
0
0
10
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
10
10
19
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
10
0
0
0
0
0
10
0
0
0
0
0
10
% F
% Gly:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
10
55
0
% H
% Ile:
10
0
10
0
0
0
10
0
0
0
91
0
0
10
0
% I
% Lys:
0
0
0
64
64
73
0
0
0
19
0
10
10
0
0
% K
% Leu:
10
0
55
0
0
0
0
0
91
0
0
19
0
10
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
82
0
0
0
0
0
0
0
64
0
10
10
10
0
% N
% Pro:
0
0
0
0
0
10
0
19
0
10
0
0
0
0
91
% P
% Gln:
0
0
0
0
10
0
0
0
0
0
0
0
0
10
0
% Q
% Arg:
0
0
0
10
0
10
19
19
0
0
0
55
10
0
0
% R
% Ser:
0
10
19
0
0
0
46
10
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
19
10
0
10
0
0
0
0
0
46
0
0
% T
% Val:
82
0
0
0
0
0
10
0
0
0
10
10
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
46
0
0
0
0
0
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _