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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CLDN23 All Species: 8.79
Human Site: Y224 Identified Species: 21.48
UniProt: Q96B33 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.22
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96B33 NP_919260.2 292 31915 Y224 L A P A I K Y Y S D G Q H R P
Chimpanzee Pan troglodytes XP_528065 290 31820 Y224 L A P A I K Y Y S D G Q H R P
Rhesus Macaque Macaca mulatta XP_001091185 289 31502 P227 Y S D G Q H R P P P A Q H R K
Dog Lupus familis XP_851151 187 19670 L137 V A L G A A G L L G L A P V S
Cat Felis silvestris
Mouse Mus musculus Q9D7D7 296 32443 Y224 L T P A I K Y Y S D G Q H R P
Rat Rattus norvegicus Q63400 219 23296 A169 G L Y V G W A A A A L Q L L G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511039 132 14342 L82 P V R A V W G L M V T S L V A
Chicken Gallus gallus XP_426312 233 25118 K183 L S F H H C C K E R R A S K T
Frog Xenopus laevis NP_001087400 213 22866 M163 K R E L G S S M Y L G W A A S
Zebra Danio Brachydanio rerio Q9YH91 208 22187 R158 T L S D A Q K R E L G A S L F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.2 90 46.9 N.A. 78.3 21.2 N.A. 26.7 47.5 20.8 22.6 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 97.5 92.8 50.6 N.A. 84.1 33.9 N.A. 33.2 57.8 38 36.6 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 20 6.6 N.A. 93.3 6.6 N.A. 6.6 6.6 6.6 6.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 26.6 13.3 N.A. 93.3 13.3 N.A. 13.3 20 6.6 13.3 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 30 0 40 20 10 10 10 10 10 10 30 10 10 10 % A
% Cys: 0 0 0 0 0 10 10 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 10 10 0 0 0 0 0 30 0 0 0 0 0 % D
% Glu: 0 0 10 0 0 0 0 0 20 0 0 0 0 0 0 % E
% Phe: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 10 % F
% Gly: 10 0 0 20 20 0 20 0 0 10 50 0 0 0 10 % G
% His: 0 0 0 10 10 10 0 0 0 0 0 0 40 0 0 % H
% Ile: 0 0 0 0 30 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 10 0 0 0 0 30 10 10 0 0 0 0 0 10 10 % K
% Leu: 40 20 10 10 0 0 0 20 10 20 20 0 20 20 0 % L
% Met: 0 0 0 0 0 0 0 10 10 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 10 0 30 0 0 0 0 10 10 10 0 0 10 0 30 % P
% Gln: 0 0 0 0 10 10 0 0 0 0 0 50 0 0 0 % Q
% Arg: 0 10 10 0 0 0 10 10 0 10 10 0 0 40 0 % R
% Ser: 0 20 10 0 0 10 10 0 30 0 0 10 20 0 20 % S
% Thr: 10 10 0 0 0 0 0 0 0 0 10 0 0 0 10 % T
% Val: 10 10 0 10 10 0 0 0 0 10 0 0 0 20 0 % V
% Trp: 0 0 0 0 0 20 0 0 0 0 0 10 0 0 0 % W
% Tyr: 10 0 10 0 0 0 30 30 10 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _